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PET Imaging in Parkinson Disease Dementia

Sponsor
Washington University School of Medicine (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT01052350
Collaborator
(none)
320
Enrollment
1
Location
287
Duration (Months)
1.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. We will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    320 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Investigations of Dementia in Parkinson Disease
    Study Start Date :
    Aug 1, 2006
    Anticipated Primary Completion Date :
    Jul 1, 2030
    Anticipated Study Completion Date :
    Jul 1, 2030

    Arms and Interventions

    Arm Intervention/Treatment
    Parkinson disease

    individuals with Parkinson disease
    healthy control

    individuals without Parkinson disease

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      50 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.
      Exclusion Criteria:

      • history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia

      • severe systemic diseases

      • inability to lie still for 90 minutes

      • metallic implants, pacemakers, or any other contraindication to MRI

      • refusal to consent to brain donation

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 NeuroClinical Research Unit (NCRU), Washington University School of Medicine Saint Louis Missouri United States 63110

      Sponsors and Collaborators

      • Washington University School of Medicine

      Investigators

      • Principal Investigator: Joel S. Perlmutter, MD, Washington University School of Medicine

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Washington University School of Medicine
      ClinicalTrials.gov Identifier:
      NCT01052350
      Other Study ID Numbers:
      • 06-0706-201103106
      First Posted:
      Jan 20, 2010
      Last Update Posted:
      Jul 13, 2022
      Last Verified:
      Jul 1, 2022
      Keywords provided by Washington University School of Medicine
      Parkinson disease
      PET imaging
      PIB
      dementia
      Additional relevant MeSH terms:
      Parkinson Disease
      Dementia

      Study Results

      No Results Posted as of Jul 13, 2022