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PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Sponsor
University of Alberta (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT04571177
Collaborator
(none)
20
Enrollment
1
Location
107
Anticipated Duration (Months)
0.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    20 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Developing PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke Patients
    Actual Study Start Date :
    Feb 1, 2016
    Anticipated Primary Completion Date :
    Dec 31, 2022
    Anticipated Study Completion Date :
    Dec 31, 2024

    Outcome Measures

    Primary Outcome Measures

    1. Compare PET brain perfusion imaging to CTP [through study completion, 1 year from start of recruitment]

      Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Age: >18 yo

    • Gender: male or female

    • Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke

    Exclusion Criteria:
      1. Planned surgical intervention
      1. Severely abnormal blood glucose level (will be excluded from FDG PET imaging)
      1. Unable to undergo CTP or PET imaging (i.e. claustrophobia)
      1. Pregnancy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Alberta Edmonton Alberta Canada T6G2B7

    Sponsors and Collaborators

    • University of Alberta

    Investigators

    • Principal Investigator: Brian Buck, Associate Professor

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    University of Alberta
    ClinicalTrials.gov Identifier:
    NCT04571177
    Other Study ID Numbers:
    • Version 1.0 28AUG2019
    First Posted:
    Sep 30, 2020
    Last Update Posted:
    Apr 7, 2022
    Last Verified:
    Apr 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Stroke
    Ischemic Stroke

    Study Results

    No Results Posted as of Apr 7, 2022