Pharmacology and Physiology of the Lower Urinary Tract

Sponsor

University College London Hospitals (Other)

Overall Status

Unknown status

CT.gov ID

NCT00662064

Collaborator

(none)

200

Enrollment

Location

Duration (Months)

2.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated.

This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.

Condition or Disease	Intervention/Treatment	Phase
Urologic Diseases

Study Design

Study Type:

Observational

Anticipated Enrollment :

200 participants

Time Perspective:

Prospective

Official Title:

Pharmacology and Physiology of the Lower Urinary Tract

Study Start Date :

Feb 1, 2002

Anticipated Primary Completion Date :

Dec 1, 2008

Anticipated Study Completion Date :

Dec 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
1 Patients with lower urinary tract dysfunction
2 Controls with normal lower urinary tract function

Outcome Measures

Primary Outcome Measures

Immunohistochemistry + PCR of bladder tissue [not specified (storage of biopsies)]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Patients with lower urinary tract dysfunction
Controls with normal lower urinary tract function

Exclusion Criteria:

Age < 18 years old
Pregnancy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery	London		United Kingdom	WC1N 3BG

Sponsors and Collaborators

University College London Hospitals

Investigators

Principal Investigator: Clare J Fowler, FRCP, Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
Principal Investigator: Suzy Elneil, PhD, MRCOG, Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK