Infrared Thermography Associated With Cutaneous Microcirculation for Detection of Brown-adipose Tissue (MICROBAT)
Study Details
Study Description
Brief Summary
Patients affected by pheochromocytoma (PHEO) have brown-adipose tissue (BAT) hyperactivation. They perform, in routine settings, a FDG PET-CT scan. The high metabolic activity of BAT and its ability to consume both glucose and fatty acid suggest that it may have potential as a therapeutic target in the treatment of obesity. However, alternative non-invasive techniques to PET-CT BAT detection still need more validation. Accordingly, our aim will be to measure the temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test in PHEO patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Objectives and Methodology:
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To analyse the change in temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test in PHEO patients.
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To check the decreased temperature and microcirculatory response after a cold test following resection of the tumor
All the patients affected by will benefit from a:
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clinical: treatments
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biological evaluations: glycemia, triglycerides, total cholesterol, HDL-C, LDL-C, plasma epinephrine and norepinephrine, urine catecholamine
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cutaneous microcirculation by means of Laser Speckle Imaging will be recorded at rest and during a cold test in the supra-clavicular region
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cutaneous microcirculation by means of Laser Doppler Flowmetry will be recorded at rest and during a cold test with one probe in the supra-clavicular region and one probe in umbilical region
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skin temperature by means of infrared thermography will be recorded at rest and during a cold test in the supra-clavicular region
Patients who will have surgery will be investigated before and after one year following resection of the tumor.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: BAT group Patients will be divided in two groups for statistical analysis: patients with detectable BAT by PET-CT (BAT+) patients with no detectable BAT by PET-CT (BAT-) |
Diagnostic Test: Infrared themrography
measurement of temperature and microcirculation of the skin overlaying BAT depots in the region of FDG-uptake detected by 18F-FDG PET/CT before and after a cold test
Other Names:
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Outcome Measures
Primary Outcome Measures
- Skin temperature in supra-clavicular region in basal condition (TSCRbasal) [Day 0]
Skin temperature in supra-clavicular region will be recorded by infrared thermography (FLIR camera) in basal condition
- Skin temperature in supra-clavicular region during a cold test (TSCRcold) [Day 0]
Skin temperature in supra-clavicular region will be recorded by infrared thermography (FLIR camera) during a cold test (feet in water at 19°C during 20min)
- Baseline difference in skin temperature in supra-clavicular region (diff TSCR) [Day 0]
diff TSCR (day 0) = TSCRcold - TSCRbasal
Secondary Outcome Measures
- Cutaneous blood flow in supra-clavicular region in basal condition (PUbasal) [Day 0]
Cutaneous blood flow in supra-clavicular region will be recorded by Laser Speckle Imaging (PeriCam) in basal condition
- Cutaneous blood flow in supra-clavicular region during a cold test (PUcold) [Day 0]
Cutaneous blood flow in supra-clavicular region will be recorded by Laser Speckle Imaging (PeriCam) during a cold test (feet in water at 19°C during 20min)
- Baseline difference in cutaneous blood flow in supra-clavicular region (∆PU) [Day 0]
diff PU (day0) =PUcold-PUbasal
- Volume of Brown Adipose Tissue detected by PET-CT [Day 0]
18FDG PET-CT will be performed and volume will be segmented by PET/CT Viewer..
- Activity of Brown Adipose Tissue detected by PET-CT [Day 0]
18FDG PET-CT will be performed and BAT activity (Standardized Uptake Value (SUV) will be segmented by PET/CT Viewer..
- Change from baseline difference in skin temperature in supra-clavicular region ( ∆ diffTSCR) at 12 months [Month 12]
∆ diff TSCR = diff TSCR(month12) - diff TSCR (day0)
- Change from baseline difference in cutaneous blood flow in supra-clavicular region ( ∆ diff PU) at 12 months [Month 12]
∆ diff PU = diff PU (month12) - diff PU (day0)
- Volume of Brown Adipose Tissue detected by PET-CT [Month 12]
18FDG PET-CT will be performed and volume will be segmented by PET/CT Viewer..
- Activity of Brown Adipose Tissue detected by PET-CT [Month 12]
18FDG PET-CT will be performed and BAT activity (Standardized Uptake Value (SUV) will be segmented by PET/CT Viewer..
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients with confirmed pheochromocytoma and/or paraganglioma
Exclusion Criteria:
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pregnant woman
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breastfeeding woman
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Pôle ENDO- Hopital la Conception APHM | Marseille | Paca | France | 13385 |
Sponsors and Collaborators
- University of Avignon
- Centre Hospitalier Henri Duffaut - Avignon
- Assistance Publique Hopitaux De Marseille
Investigators
- Principal Investigator: Françoise Latil-Plat, Centre Hospitalier Henri Duffaut - Avignon
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- UAPV_180620_AVJ