Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults

• Sponsor: University of Southern Denmark (Other)
• Overall Status: Completed
• CT.gov ID: NCT02075944
• Collaborator: (none)
• Enrollment: 130
• Location: 1
• Arms: 3
• Duration (Months): 3.9
• Patients Per Site Per Month: 33

Study Details

Study Description

Brief Summary

The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.

Condition or Disease	Intervention/Treatment	Phase
Physical Conditioning, Human; Cognition	Behavioral: High intensity aerobic exercise; Behavioral: Low intensity aerobic exercise	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 130 participants
• Allocation: Randomized
• Intervention Model: Factorial Assignment
• Masking: Single (Investigator)
• Primary Purpose: Supportive Care
• Official Title: Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults Aged 15-21 Years
• Study Start Date: Feb 1, 2014
• Actual Primary Completion Date: Jun 1, 2014
• Actual Study Completion Date: Jun 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Experimental: High intensity aerobic exercise 30 minutes of high intensity aerobic exercise 3 times a weeks for 9 weeks - incorporation interval training	Behavioral: High intensity aerobic exercise
Experimental: Low intensity aerobic exercise 30 minutes of low intensity aerobic exercise 3 times a weeks for 9 weeks	Behavioral: Low intensity aerobic exercise
No Intervention: Control No intervention. Participants are told not to make any changes in their everyday life

Outcome Measures

Primary Outcome Measures

1. The Flanker Task [9 weeks]

2. The AX-Continuous Performance test [9 weeks]

3. Brain-derived neurotrophic factor [9 weeks]

Secondary Outcome Measures

1. Intelligence quotient [9 weeks]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 15 Years to 21 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• age 15-21

Exclusion Criteria:

• injury preventing one from being physically active

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Southern Denmark	Odense		Denmark	5000

Sponsors and Collaborators

• University of Southern Denmark

Investigators

• Principal Investigator: Anne K Thorsen, Cand. Scient, University of Southern Denmark

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Anna Bugge, Post Doc, PhD, University of Southern Denmark
• ClinicalTrials.gov Identifier: NCT02075944
• Other Study ID Numbers: S-20130171
• First Posted: Mar 3, 2014
• Last Update Posted: Jun 26, 2014
• Last Verified: Jun 1, 2014

• Keywords provided by Anna Bugge, Post Doc, PhD, University of Southern Denmark: Aerobic exercise; Cognitive function; Executive function; Brain-derived neurotrophic factor

Study Results

No Results Posted as of Jun 26, 2014