EXEBRAIN: Molecular and Functional Neurobiology of Physical Exercise

• Sponsor: Turku University Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT02615756
• Collaborator: Academy of Finland (Other), Novo Nordisk A/S (Industry), Juho Vainio Foundation (Other), University of Turku (Other)
• Enrollment: 24
• Location: 1
• Arm: 1
• Duration (Months): 62
• Patients Per Site Per Month: 0.4

Study Details

Study Description

Brief Summary

In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

Condition or Disease	Intervention/Treatment	Phase
Physical Exercise Behavior (Liking/Aversion)	Behavioral: Exercise	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 24 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Molecular and Functional Neurobiology of Physical Exercise
• Study Start Date: Apr 1, 2013
• Actual Primary Completion Date: Jun 1, 2018
• Actual Study Completion Date: Jun 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Physical exercise	Behavioral: Exercise

Outcome Measures

Primary Outcome Measures

1. Binding of [11C]carfentanil in brain confirmed by positron emission tomography [Baseline and 20 min after physical exercise completion]

   Change in binding of [11C]carfentanil in baseline and 20 min after physical exercise completion

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 65 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

1. Native Finnish speaker

2. Age > 18 years

3. Western Caucasian origin

Exclusion Criteria:

1. Age < 18 or > 65

2. History or current mental disorder

3. BMI > 27 kg/m2

4. Use of drugs that influence the central nervous system, including nicotine

5. Poor compliance

6. Any chronic medical defect or injury which hinder or interfere everyday life

7. Eating disorder

8. Current or past excessive use of alcohol or substance abuse

9. Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv

10. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

11. Presence of any ferromagnetic objects that would make MR imaging contraindicated

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Turku PET Centre	Turku		Finland	20810

Sponsors and Collaborators

• Turku University Hospital
• Academy of Finland
• Novo Nordisk A/S
• Juho Vainio Foundation
• University of Turku

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Turku University Hospital
• ClinicalTrials.gov Identifier: NCT02615756
• Other Study ID Numbers: 19/180/2013
• First Posted: Nov 26, 2015
• Last Update Posted: Mar 9, 2021
• Last Verified: Mar 1, 2021

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Study Results

No Results Posted as of Mar 9, 2021