Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation
Study Details
Study Description
Brief Summary
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values. In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. For example, the extent to which subjective symptoms correlate with physiological impairments are not known.
This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values.
In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Covid19 Patients aged >18 years with confirmed Covid19 disease with symptoms >12 weeks, not better explained by other disease |
Diagnostic Test: Physiological testing
Cardiopulmonary exercise testing, Lung Function Testing and in some cases echocardiography. 20 subjects will perform DNA-methylation testing.
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Outcome Measures
Primary Outcome Measures
- Peak Oxygen Consumption (VO2peak) [At baseline]
Cross-sectional evaluation of VO2peak and the association with symptoms
Secondary Outcome Measures
- Peak Oxygen Consumption (VO2peak) [In subset of subjects at 1 year]
Improvement in VO2peak over 1 year
- VE/VCO2-slope [At baseline, in subset at 1 year]
Cross-sectional evaluation of VE/VCO2 and the association with symptoms
- Diffusion Capacity (DLCOc) [At baseline, in subset at 1 year]
Cross-sectional evaluation of DLCOc and the association with symptoms
- Forced Expiratory Volume in 1 second (FEV1) [At baseline, in subset at 1 year]
Cross-sectional evaluation of FEV1 and the association with symptoms
- Forced Vital Capacity (FVC) [At baseline, in subset at 1 year]
Cross-sectional evaluation of FVC and the association with symptoms
- Total Lung Capacity (TLC) [At baseline, in subset at 1 year]
Cross-sectional evaluation of TLC and the association with symptoms
Eligibility Criteria
Criteria
Inclusion Criteria:
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Confirmed or clinically highly suspected Covid19-infection
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Symptom duration at least 12 weeks following first occurence of symptoms
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No other disease that better could explain the symptoms than Covid19
Exclusion Criteria:
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Age <18 years
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Unability to perform a maximal exercise test
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Unability to understand written or spoken Swedish
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Dept Health, Medicine and Caring Sciences | Linköping | Östergötland | Sweden | 58737 |
Sponsors and Collaborators
- Linkoeping University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2021-01620