AHS-2: Plant-based Diets and Risk of Cancer in the Adventist Health Study-2

Sponsor

Loma Linda University (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT03615599

Collaborator

National Cancer Institute (NCI) (NIH), World Cancer Research Fund International (Other), Ardmore Institute of Health (Other)

96,000

Enrollment

Location

275

Anticipated Duration (Months)

349.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.

Condition or Disease	Intervention/Treatment	Phase
Cancer, Breast Cancer, Colorectal Cancer, Prostate

Detailed Description

The Adventist Health Study-2 (AHS-2) is a large national cohort of 96,000 Seventh-day Adventists in the U.S. and Canada. The study is searching for associations between diet and risk of common and medium frequency cancers (breast, prostate, colorectal, lung, uterus, pancreas, melanoma of skin). This cohort is unusual in that about half are vegetarian, many eat soy at Asian levels, and many have very low or absent dairy intake while others eat normal amounts of dairy. Thus observations on these people, many of whom have contrasting dietary habits, may provide insights about diet and cancer, so supporting dietary changes that could be readily adopted by many.

Study Design

Study Type:

Observational

Actual Enrollment :

96000 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Cancer Epidemiology in Seventh-day Adventists

Actual Study Start Date :

Feb 1, 2002

Actual Primary Completion Date :

Dec 31, 2013

Anticipated Study Completion Date :

Dec 31, 2024

Arms and Interventions

Arm	Intervention/Treatment
Seventh-day Adventists This is a prospective cohort study of 96,000 members of the Seventh-day Adventists Church in the United States and Canada age 30 and older at the time of enrollment who are proficient in English language.

Outcome Measures

Primary Outcome Measures

Incident cases of breast cancer among subjects with documented dietary habits. [Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.]
Incident cases of breast cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.

Secondary Outcome Measures

Incident cases of prostate cancer among subjects with documented dietary intakes. [Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.]
Incident cases of prostate cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.

Other Outcome Measures

Incident cases of colorectal cancer among subjects with documented dietary habits. [Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.]
Incident cases of colorectal cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.