Bortezomib or Carfilzomib With Lenalidomide and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma
Study Details
Study Description
Brief Summary
This randomized phase III trial studies bortezomib, lenalidomide, and dexamethasone to see how well they work compared to carfilzomib, lenalidomide, and dexamethasone in treating patients with newly diagnosed multiple myeloma. Bortezomib and carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may help the immune system kill abnormal blood cells or cancer cells. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether bortezomib, lenalidomide, and dexamethasone are more or less effective than carfilzomib, lenalidomide, and dexamethasone in treating patients with multiple myeloma
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
PRIMARY OBJECTIVES:
-
To compare the overall survival between two strategies of lenalidomide maintenance following induction with a proteasome inhibitor? immunomodulatory drug (IMiD) combination: limited duration of maintenance (24 months) versus indefinite maintenance therapy until disease progression.
-
To compare progression-free survival between bortezomib, lenalidomide, and dexamethasone (VRd) and carfilzomib, lenalidomide, and dexamethasone (CRd) induction followed by lenalidomide maintenance in patients with newly diagnosed symptomatic multiple myeloma.
SECONDARY OBJECTIVES:
-
To compare the progression-free survival between two strategies of lenalidomide maintenance following induction with a proteasome inhibitor?IMiD combination: limited duration of maintenance (24 months) or indefinite maintenance therapy until disease progression.
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To compare induction rates of response between VRd and CRd arms. III. To evaluate time to progression, duration of response and overall survival between VRd and CRd induction therapy.
-
To compare induction rates of toxicity between VRd and CRd arms. V. To evaluate toxicity during lenalidomide maintenance. VI. To compare minimal residual disease (MRD) negative rates between VRd and CRd arms at end of induction therapy.
TERTIARY OBJECTIVES:
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To compare the short and long-term health-related quality of life impact between the two strategies of lenalidomide maintenance.
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To compare the impact on health-related quality of life between VRd and CRd induction therapy.
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To evaluate the association between early induction response and change in health-related quality of life.
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To describe changes in health-related quality of life during the induction, active maintenance and observation phases.
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To evaluate correlation between treatment adherence during maintenance and health-related quality of life.
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To compare MRD negative rates between the two strategies of lenalidomide maintenance.
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To compare MRD negative rates between VRd and CRd arms during induction therapy.
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To examine patterns of change in MRD levels over time and examine conversion from detectable to MRD negative status.
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To evaluate agreement and association between International Myeloma Working Group (IMWG) and MRD based disease-free status.
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To describe the mutational profile of newly diagnosed multiple myeloma. XI. To identify mutations associated with resistance to VRd and CRd induction therapy.
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To identify expression profiles associated with MRD negative status with each induction therapy.
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To determine the ability of MRD status at induction end to predict short-term and long-term overall and progression-free survival.
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To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).
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To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.
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To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.
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To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.
OUTLINE:
INDUCTION: Patients are randomized to 1 of 2 treatment arms.
ARM A: Patients receive bortezomib subcutaneously (SC) or intravenously (IV) on days 1, 4, 8, and 11 of courses 1-8 and days 1 and 8 of courses 9-12; lenalidomide orally (PO) daily on days 1-14; and dexamethasone PO daily on days 1, 2, 4, 5, 8, 9, 11, and 12 of courses 1-8 and days 1, 2, 8, and 9 of courses 9-12. Treatment repeats every 3 weeks for 12 courses in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive carfilzomib IV over 30 minutes on days 1, 2, 8, 9, 15, and 16; lenalidomide PO daily on days 1-21; and dexamethasone PO on days 1, 8, 15, and 22. Treatment repeats every 4 weeks for 9 courses in the absence of disease progression or unacceptable toxicity.
MAINTENANCE: After completion of induction therapy (or completion of at least 6 courses in Arm A but stopped early due to unacceptable toxicity, or at least 4 courses in Arm B but stopped early due to unacceptable toxicity), patients are then randomized to 1 of 2 maintenance treatment arms.
ARM C: Patients receive lenalidomide PO daily on days 1-21. Treatment repeats every 4 weeks for 24 courses in the absences of disease progression or unacceptable toxicity.
ARM D: Patients receive lenalidomide PO daily on days 1-21. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually for 10 years.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm A (bortezomib, lenalidomide, dexamethasone) Patients receive bortezomib SC or IV on days 1, 4, 8, and 11 of courses 1-8 and days 1 and 8 of courses 9-12; lenalidomide PO daily on days 1-14; and dexamethasone PO daily on days 1, 2, 4, 5, 8, 9, 11, and 12 of courses 1-8 and days 1, 2, 8, and 9 of courses 9-12. Treatment repeats every 3 weeks for 12 courses in the absence of disease progression or unacceptable toxicity. |
Drug: Bortezomib
Given SC or IV
Other Names:
Drug: Dexamethasone
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Optional correlative studies
Drug: Lenalidomide
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
|
| Experimental: Arm B (carfilzomib, lenalidomide, dexamethasone) Patients receive carfilzomib IV over 30 minutes on days 1, 2, 8, 9, 15, and 16; lenalidomide PO daily on days 1-21; and dexamethasone PO on days 1, 8, 15, and 22. Treatment repeats every 4 weeks for 9 courses in the absence of disease progression or unacceptable toxicity. |
Drug: Carfilzomib
Given IV
Other Names:
Drug: Dexamethasone
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Optional correlative studies
Drug: Lenalidomide
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
|
| Experimental: Arm C (lenalidomide) Patients receive lenalidomide PO daily on days 1-21. Treatment repeats every 4 weeks for 24 courses in the absences of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Optional correlative studies
Drug: Lenalidomide
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
|
| Experimental: Arm D (lenalidomide) Patients receive lenalidomide PO daily on days 1-21. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Optional correlative studies
Drug: Lenalidomide
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Overall survival (OS) for the maintenance analysis [From the maintenance randomization to death due to any cause or, censored at the date last known alive, assessed up to 15 years]
The Kaplan-Meier (KM) method will be used to describe the overall survival function by arm. Sensitivity analysis will be done to evaluate OS in the subset of eligible patients and censoring patients at time of non-protocol therapy.
- Progression-free survival for the induction analysis [From the induction randomization until the earlier of progression or death due to any cause, assessed up to 15 years]
The Kaplan-Meier method will be used to describe the progression-free survival function by arm using all data while ignoring maintenance.
Secondary Outcome Measures
- Progression-free survival for the maintenance analysis [From the maintenance randomization until the earlier of progression or death due to any cause, assessed up to 15 years]
Weighted Cox regression will be used.
- Overall survival for the induction analysis [From induction randomization to death due to any cause, or censored at the date last known alive, assessed up to 15 years]
The KM method will be used.
- Response rates including partial response (PR), very good partial response (VGPR), immunofixation negative complete response (IF-CR) and complete response (CR) [At 2.8 months]
Will be compared between induction arms using Fisher?s exact test.
- Response rates including PR, VGPR, IF-CR and CR [At 8.3 months]
Will be compared between induction arms using Fisher?s exact test.
- Time to progression (TTP) for the induction analysis [From the induction randomization to progression, or censored at the date of last disease evaluation for those without progression reported, assessed up to 15 years]
TTP distributions will be estimated by induction arm using Kaplan-Meier methods.
- Duration of response (DOR) for the induction analysis [From first objective response (partial response or better) since induction randomization until the earlier of progression or death due to any cause, or censored at date of last disease evaluation for those without events reported, assessed up to 15 years]
Duration of response will be estimated using Kaplan-Meier methods in the subset of patients achieving partial response or better while on induction therapy.
- Incidence of overall grade 3 or higher non-hematologic toxicity and grade 3 or higher toxicity by type during induction, active maintenance and observation phases using Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 [Up to 15 years]
Fisher?s exact test will be used.
- Incidence of grade 2 or higher peripheral neuropathy and cardiac toxicity during induction phase assessed using CTCAE version 5.0 [Up to 36 weeks]
Fisher?s exact test will be used.
- Minimal residual disease (MRD) negative rates [At 8.3 months after induction randomization]
MRD evaluation by multiparametric flow cytometry will be conducted and patients classified as MRD negative, MRD positive or not evaluable. At each time point, MRD negative rates with two-sided 95% exact confidence intervals on each arm will be estimated. Patterns of change over time in MRD will also be evaluated using longitudinal regression analysis with general linear mixed effects models and GEE semi-parametric models. MRD negative rates will be compared between either induction or maintenance arms depending on the assessment time point using the Mantel-Haenszel test stratified either on intent to transplant at progression or induction arm (Step 1 and 2 stratification factors, respectively).
- Change in the Functional Assessment of Cancer Therapy-Neurotoxicity Trial Outcome Index (FACT-Ntx TOI) for the transition to maintenance analysis [From week 36 (the end) of induction therapy to week 24 (end of course 6) of maintenance therapy]
Will be analyzed using linear mixed models.
- Change in the FACT-Ntx TOI for the short-term maintenance analysis [From the end of 2 years of maintenance to 3 years post maintenance randomization]
Will be analyzed using linear mixed models.
- Change in the FACT-Ntx TOI for the long-term maintenance analysis [From the end of 2 years of maintenance to 5 years post maintenance randomization]
Will be analyzed using linear mixed models.
- Change in the FACT-Ntx TOI for the end of induction analysis [From baseline (induction randomization) to 36 weeks (end) of induction therapy]
Will be analyzed using linear mixed models.
- Change in the FACT-Ntx TOI for the early induction analysis [From baseline (induction randomization) to 2.8 months of induction therapy]
Will be analyzed using linear mixed models.
- Levels and changes in the FACT-Ntx TOI and Functional Assessment of Cancer Therapy- Multiple Myeloma (FACT-MM) during induction, active maintenance and observation phases [Up to 15 years]
Will be analyzed using linear mixed models.
- Time to worsening of FACT-Ntx TOI for the induction analysis [From the baseline assessment at induction randomization to a decrease of 7 points, assessed up to 15 years]
Will be analyzed with KM methods and Cox regression.
- Time to worsening of FACT-MM for the maintenance analysis [From the baseline assessment at maintenance randomization to a decrease of 4 points, assessed up to 15 years]
Will be analyzed with KM methods and Cox regression.
Other Outcome Measures
- MRD negative rates [At 2.8 months after induction randomization]
MRD evaluation by multiparametric flow cytometry will be conducted and patients classified as MRD negative, MRD positive or not evaluable. At each time point, MRD negative rates with two-sided 95% exact confidence intervals on each arm will be estimated. Patterns of change over time in MRD will also be evaluated using longitudinal regression analysis with general linear mixed effects models and GEE semi-parametric models. MRD negative rates will be compared between either induction or maintenance arms depending on the assessment time point using the Mantel-Haenszel test stratified either on intent to transplant at progression or induction arm (Step 1 and 2 stratification factors, respectively).
- MRD negative rates [At 2 years after maintenance randomization]
MRD evaluation by multiparametric flow cytometry will be conducted and patients classified as MRD negative, MRD positive or not evaluable. At each time point, MRD negative rates with two-sided 95% exact confidence intervals on each arm will be estimated. Patterns of change over time in MRD will also be evaluated using longitudinal regression analysis with general linear mixed effects models and GEE semi-parametric models. MRD negative rates will be compared between either induction or maintenance arms depending on the assessment time point using the Mantel-Haenszel test stratified either on intent to transplant at progression or induction arm (Step 1 and 2 stratification factors, respectively).
- MRD negative rates [At 3 years after maintenance randomization]
MRD evaluation by multiparametric flow cytometry will be conducted and patients classified as MRD negative, MRD positive or not evaluable. At each time point, MRD negative rates with two-sided 95% exact confidence intervals on each arm will be estimated. Patterns of change over time in MRD will also be evaluated using longitudinal regression analysis with general linear mixed effects models and GEE semi-parametric models. MRD negative rates will be compared between either induction or maintenance arms depending on the assessment time point using the Mantel-Haenszel test stratified either on intent to transplant at progression or induction arm (Step 1 and 2 stratification factors, respectively).
- Change in mutation status [Baseline up to 15 years]
Descriptive statistics (absolute frequencies, percentages, mean, standard deviation [SD], median, range) will be used to characterize the study cohort by mutation incidence and expression levels at all time-points.
- Change in gene expression levels [Baseline up to 15 years]
Descriptive statistics (absolute frequencies, percentages, mean, SD, median, range) will be used to characterize the study cohort by mutation incidence and expression levels at all time-points. Association of genotype data (binary) with categorical baseline patient and disease characteristics will be evaluated using chi-squared test or, if appropriate, Cochran-Armitage trend test. The Wilcoxon-rank sum test or, if appropriate, the Jonckheere-Terpstra test for trend will be used to assess differential expression levels with baseline patient and disease characteristic groups. The Kaplan-Meier method will be used to estimate progression-free and overall survival distributions and Cox regression to estimate hazard ratios by genotype status.
- Circulating plasma cells and plasma cell proliferation [Up to 15 years]
With samples submitted pre-registration, multiparametric flow cytometry will quantify circulating plasma cells (cPC) in terms of number of clonal events/150,000 collected total events and plasma cell proliferation in terms of the plasma cell labeling index (PCLI) percentage. The Kaplan-Meier method will be used to estimate induction progression-free survival and overall survival distributions and Cox regression used to estimate hazard ratios by dichotomized cPC and PCLI.
Eligibility Criteria
Criteria
Inclusion Criteria:
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STEP I: Patients must be diagnosed with symptomatic standard-risk multiple myeloma (SR-MM) as defined by all of the following (except gene expression profile [GEP]70 status if unknown):
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No evidence of t(14;16) by fluorescence in situ hybridization (FISH) testing on bone marrow or not available
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No evidence of t(14:20) by FISH testing on bone marrow or not available
-
No evidence of deletion 17p by FISH testing on bone marrow
-
FISH should be from within 90 days of registration
-
NOTE: If the FISH result states that no immunoglobulin heavy chain (IgH) abnormality is present, both t(14;16) and t(14;20) can be considered negative; in addition, if the patient has a t(11;14) or t(4;14) translocation present, they can be considered negative for t(14;16) and t(14;20); if testing for t(14;16) or t(14;20) could not be performed for lack of sufficient material or non-availability of the probe in the test panel, patients can be enrolled on the study
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Standard Risk GEP70 signature within the past 90 days (only if GEP has been done and results are available)
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NOTE: GEP testing is NOT a requirement for the study; if the test has been done, patients found to have a GEP70 status of high-risk will not be eligible
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Serum lactate dehydrogenase (LDH) =< 2 x upper limit of normal (ULN) within the past 28 days
-
No more than 20% circulating plasma cells on peripheral blood smear differential or 2,000 plasma cells/microliter on white blood cell (WBC) differential of peripheral blood within the past 90 days
-
NOTE: This is NOT the plasma cell % from the marrow aspirate
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STEP I: Patients must have measurable or evaluable disease as defined by having one or more of the following, obtained within 28 days prior to randomization:
-
= 1 g/dL monoclonal protein (M-protein) on serum protein electrophoresis
-
= 200 mg/24 hours (hrs) of monoclonal protein on a 24 hour urine protein electrophoresis
-
Involved free light chain >= 10 mg/dL or >= 100 mg/L AND abnormal serum immunoglobulin kappa to lambda free light chain ratio (< 0.26 or > 1.65)
-
Monoclonal bone marrow plasmacytosis >= 30% (evaluable disease)
-
Serum protein electrophoresis (SPEP), urine protein electrophoresis (UPEP), and serum free light chain (FLC) assay are required to be performed within 28 days prior to randomization; a bone marrow biopsy and/or aspirate is required within 28 days if bone marrow is being followed for response
-
NOTE: UPEP (on a 24-hour collection) is required, no substitute method is acceptable; urine must be followed monthly if the baseline urine M-spike is
= 200 mg/24 hr; please note that if both serum and urine M-components are present, both must be followed in order to evaluate response
-
NOTE: The serum free light chain test is required to be done if the patient does not have measurable disease in the serum or urine; measurable disease in the serum is defined as having a serum M-spike >= 1 g/dL; measurable disease in the urine is defined as having a urine M-spike >= 200 mg/24 hr
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STEP I: Hemoglobin >= 8 g/dL (obtained within 28 days prior to randomization)
-
STEP I: Untransfused platelet count >= 75,000 cells/mm^3 (obtained within 28 days prior to randomization)
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STEP I: Absolute neutrophil count >= 1000 cells/mm^3 (obtained within 28 days prior to randomization)
-
STEP I: Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior to randomization)
-
STEP I: Bilirubin =< 1.5 mg/dL (obtained within 28 days prior to randomization)
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STEP I: Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) and serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) < 2.5 times the upper limit of normal (obtained within 28 days prior to randomization)
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STEP I: Patients must have received no more than one cycle (4 weeks or less) of prior chemotherapy and no more than 160 mg of prior dexamethasone (or equivalent dose of prednisone) for treatment of symptomatic myeloma; they should not have been exposed to lenalidomide, bortezomib or carfilzomib for treatment of symptomatic myeloma; prior radiation therapy to symptomatic lesions is allowed provided there are no residual toxicity related to radiation and blood counts that meet the study requirements
-
STEP I: Prior systemic glucocorticoid use for the treatment of non-malignant disorders is permitted; prior or concurrent topical or localized glucocorticoid therapy to treat non-malignant comorbid disorders is permitted
-
STEP I: Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last 6 months
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STEP I: Patients must not have uncontrolled intercurrent illness including uncontrolled hypertension, symptomatic congestive heart failure, unstable angina, uncontrolled cardiac arrhythmia, uncontrolled psychiatric illness or social situation that would limit compliance with the study, or a prior history of Stevens Johnson syndrome
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STEP I: Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 (performance status [PS] 3 allowed if secondary to pain)
-
STEP I: Patients with monoclonal gammopathy of undetermined significance or asymptomatic multiple myeloma are not eligible
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STEP I: Patients must not have grade 2 or higher peripheral neuropathy by Common Terminology Criteria for Adverse Events (CTCAE) 4.0
-
STEP I: Patients must not have active, uncontrolled infection
-
STEP I: Patients may have a history of current or previous deep vein thrombosis or pulmonary embolism but must be willing to take some form of anti-coagulation as prophylaxis if they are not currently on full-dose anticoagulation
-
STEP I: Patients should not have New York Heart Association classification III or IV heart failure or myocardial infarction within the previous 6 months
-
STEP I: Patients with a history of prior malignancy are eligible provided they were treated with curative intent and do not require active therapy (currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma ?in situ? of the cervix or breast are not excluded)
-
STEP I: Females of childbearing potential (FCBP)* must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide throughout the entire duration of study treatment, and for 28 days after the last dose of lenalidomide; FCBP must also agree to ongoing pregnancy testing; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure; female subjects must agree to use contraception or abstinence for 30 days after last dose of carfilzomib
-
A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:
- has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months
-
STEP I: Sexually active males must be willing to use a condom (even if they have undergone a prior vasectomy) while having intercourse, while taking lenalidomide and for 28 days after stopping lenalidomide; male subjects must also agree to abstain from donating blood, semen, or sperm during study participation and for at least 28 days after discontinuation from lenalidomide; male subjects must be willing to use condoms for 90 days after discontinuation of carfilzomib
-
STEP I: The following patients will be excluded:
-
Pregnant women
-
Nursing women
-
STEP I: Human immunodeficiency virus (HIV) infection is not excluded; known HIV positive patients must meet the following criteria:
-
Cluster of differentiation (CD)4 cell count >= 350/mm^3
-
No history of acquired immune deficiency syndrome (AIDS)-related illness
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Not currently prescribed zidovudine or stavudine
-
STEP I: Patient enrolling to this study must agree to register to the mandatory RevAssist program, and be willing and able to comply with the requirements of RevAssist
-
STEP II: Patients must have complete induction without experiencing progression or patients must have received at least 6 cycles on Arm A and 4 cycles on Arm B but stopped induction therapy due to adverse events
-
STEP II: Step 2 registration must be within 6 weeks of completing step 1 therapy
-
STEP II: Patients must not have received any non-protocol therapy outside of the assigned induction therapy including stem cell transplant
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STEP II: ECOG performance status 0, 1, or 2 (PS 3 allowed if secondary to pain)
-
STEP II: Any adverse event related to step 1 therapy must have resolved to grade 2 or less
-
STEP II: Hemoglobin >= 8 g/dL (within 28 days prior to randomization to Step II)
-
STEP II: Platelet count >= 75,000 cells/mm^3 (within 28 days prior to randomization to Step II)
-
STEP II: Absolute neutrophil count >= 1000 cells/mm^3 (within 28 days prior to randomization to Step II)
-
STEP II: Calculated creatinine clearance >= 30 mL/min (within 28 days prior to randomization to Step II)
-
STEP II: Bilirubin =< 1.5 mg/dL (within 28 days prior to randomization to Step II)
-
STEP II: SGPT (ALT) and SGOT (AST) < 2.5 times the upper limit of normal (within 28 days prior to randomization to Step II)
-
STEP II: Females of childbearing potential (FCBP)* must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide throughout the entire duration of study treatment, and for 28 days after the last dose of lenalidomide; FCBP must also agree to ongoing pregnancy testing; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
-
A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:
- has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months
-
STEP II: Sexually active males must be willing to use a condom (even if they have undergone a prior vasectomy) while having intercourse, while taking lenalidomide and for 28 days after stopping lenalidomide; male subjects must also agree to abstain from donating blood, semen, or sperm during study participation and for at least 28 days after discontinuation from lenalidomide; males must agree to use contraception and agree to not donate sperm for at least 90 days after the last day of carfilzomib
-
STEP II: The following patients will be excluded:
-
Pregnant women
-
Nursing women
-
STEP II: Patient enrolling to this study must agree to register to the mandatory RevAssist program and be willing and able to comply with the requirements of RevAssist
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 2 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 3 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 4 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 5 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 6 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 7 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 8 | Mayo Clinic in Arizona | Scottsdale | Arizona | United States | 85259 |
| 9 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 10 | Veteran's Administration Medical Center | Little Rock | Arkansas | United States | 72205 |
| 11 | Kaiser Permanente-Deer Valley Medical Center | Antioch | California | United States | 94531 |
| 12 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 13 | Sutter Auburn Faith Hospital | Auburn | California | United States | 95602 |
| 14 | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | United States | 95603 |
| 15 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 16 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 17 | Mills-Peninsula Medical Center | Burlingame | California | United States | 94010 |
| 18 | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | United States | 95682 |
| 19 | Eden Hospital Medical Center | Castro Valley | California | United States | 94546 |
| 20 | UC Irvine Health Cancer Center-Newport | Costa Mesa | California | United States | 92627 |
| 21 | Sutter Davis Hospital | Davis | California | United States | 95616 |
| 22 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 23 | Palo Alto Medical Foundation-Fremont | Fremont | California | United States | 94538 |
| 24 | Kaiser Permanente-Fresno | Fresno | California | United States | 93720 |
| 25 | Saint Jude Medical Center | Fullerton | California | United States | 92835 |
| 26 | Fremont - Rideout Cancer Center | Marysville | California | United States | 95901 |
| 27 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 28 | Kaiser Permanente-Modesto | Modesto | California | United States | 95356 |
| 29 | Palo Alto Medical Foundation-Camino Division | Mountain View | California | United States | 94040 |
| 30 | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California | United States | 94040 |
| 31 | Sutter Cancer Research Consortium | Novato | California | United States | 94945 |
| 32 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 33 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 34 | Palo Alto Medical Foundation Health Care | Palo Alto | California | United States | 94301 |
| 35 | Eisenhower Medical Center | Rancho Mirage | California | United States | 92270 |
| 36 | Kaiser Permanente-Redwood City | Redwood City | California | United States | 94063 |
| 37 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 38 | Kaiser Permanente-Roseville | Roseville | California | United States | 95661 |
| 39 | Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | United States | 95661 |
| 40 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 41 | Kaiser Permanente Downtown Commons | Sacramento | California | United States | 95814 |
| 42 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 43 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 44 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 45 | Kaiser Permanente - Sacramento | Sacramento | California | United States | 95825 |
| 46 | California Pacific Medical Center-Pacific Campus | San Francisco | California | United States | 94115 |
| 47 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 48 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 49 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 50 | Kaiser Permanente-San Rafael | San Rafael | California | United States | 94903 |
| 51 | Kaiser San Rafael-Gallinas | San Rafael | California | United States | 94903 |
| 52 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051 |
| 53 | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California | United States | 95065 |
| 54 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 55 | Sutter Pacific Medical Foundation | Santa Rosa | California | United States | 95403 |
| 56 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 57 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 58 | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | United States | 94086 |
| 59 | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California | United States | 96161 |
| 60 | Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | United States | 95687 |
| 61 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 62 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 63 | Sutter Solano Medical Center/Cancer Center | Vallejo | California | United States | 94589 |
| 64 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 65 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 66 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 67 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 68 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 69 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 70 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 71 | Denver Health Medical Center | Denver | Colorado | United States | 80204 |
| 72 | Kaiser Permanente-Franklin | Denver | Colorado | United States | 80205 |
| 73 | National Jewish Health-Main Campus | Denver | Colorado | United States | 80206 |
| 74 | The Women's Imaging Center | Denver | Colorado | United States | 80209 |
| 75 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 76 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 77 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 78 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 79 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 80 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 81 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 82 | Colorado Cancer Research Program NCORP | Denver | Colorado | United States | 80222 |
| 83 | Mercy Medical Center | Durango | Colorado | United States | 81301 |
| 84 | Southwest Oncology PC | Durango | Colorado | United States | 81301 |
| 85 | Comprehensive Cancer Care and Research Institute of Colorado LLC | Englewood | Colorado | United States | 80113 |
| 86 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 87 | Mountain Blue Cancer Care Center | Golden | Colorado | United States | 80401 |
| 88 | National Jewish Health-Western Hematology Oncology | Golden | Colorado | United States | 80401 |
| 89 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 90 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 91 | Rocky Mountain Cancer Centers-Greenwood Village | Greenwood Village | Colorado | United States | 80111 |
| 92 | Good Samaritan Medical Center | Lafayette | Colorado | United States | 80026 |
| 93 | Kaiser Permanente-Rock Creek | Lafayette | Colorado | United States | 80026 |
| 94 | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | United States | 80228 |
| 95 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 96 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 97 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 98 | Kaiser Permanente-Lone Tree | Lone Tree | Colorado | United States | 80124 |
| 99 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 100 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 101 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 102 | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | United States | 80501 |
| 103 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 104 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 105 | Rocky Mountain Cancer Centers-Parker | Parker | Colorado | United States | 80138 |
| 106 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 107 | Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado | United States | 81008 |
| 108 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 109 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 110 | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | United States | 06418 |
| 111 | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | United States | 06824 |
| 112 | Yale-New Haven Shoreline Medical Center | Guilford | Connecticut | United States | 06437 |
| 113 | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | United States | 06105 |
| 114 | Yale University | New Haven | Connecticut | United States | 06520 |
| 115 | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | United States | 06473 |
| 116 | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut | United States | 06477 |
| 117 | Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | United States | 06790 |
| 118 | Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | United States | 06611 |
| 119 | Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | United States | 06708 |
| 120 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 121 | Christiana Gynecologic Oncology LLC | Newark | Delaware | United States | 19713 |
| 122 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 123 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 124 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 125 | Regional Hematology and Oncology PA | Newark | Delaware | United States | 19713 |
| 126 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 127 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 128 | Nanticoke Memorial Hospital | Seaford | Delaware | United States | 19973 |
| 129 | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | United States | 19801 |
| 130 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 131 | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | United States | 33442 |
| 132 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 133 | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | United States | 33176 |
| 134 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 135 | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | United States | 33324 |
| 136 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 137 | Northside Hospital-Forsyth | Cumming | Georgia | United States | 30041 |
| 138 | Atlanta VA Medical Center | Decatur | Georgia | United States | 30033 |
| 139 | Gwinnett Medical Center | Lawrenceville | Georgia | United States | 30046 |
| 140 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 141 | Hawaii Oncology Inc-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 142 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 143 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 144 | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii | United States | 96813 |
| 145 | Hawaii Oncology Inc-POB I | Honolulu | Hawaii | United States | 96813 |
| 146 | Island Urology | Honolulu | Hawaii | United States | 96813 |
| 147 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 148 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 149 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 150 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 151 | Hawaii Oncology Inc-Kuakini | Honolulu | Hawaii | United States | 96817 |
| 152 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 153 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 154 | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | United States | 96819 |
| 155 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 156 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
| 157 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 158 | Saint Luke's Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
| 159 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 160 | Kootenai Medical Center | Coeur d'Alene | Idaho | United States | 83814 |
| 161 | Walter Knox Memorial Hospital | Emmett | Idaho | United States | 83617 |
| 162 | Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 163 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 164 | Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 165 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 166 | Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 167 | Kootenai Cancer Center | Post Falls | Idaho | United States | 83854 |
| 168 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 169 | Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 170 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 171 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 172 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 173 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 174 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 175 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 176 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 177 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 178 | Mount Sinai Hospital Medical Center | Chicago | Illinois | United States | 60608 |
| 179 | Weiss Memorial Hospital | Chicago | Illinois | United States | 60640 |
| 180 | Presence Saint Joseph Hospital-Chicago | Chicago | Illinois | United States | 60657 |
| 181 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 182 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 183 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 184 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 185 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 186 | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois | United States | 60007 |
| 187 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 188 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 189 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 190 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 191 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 192 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 193 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 194 | AMITA Health Cancer Institute and Outpatient Center | Hinsdale | Illinois | United States | 60521 |
| 195 | Hinsdale Hematology Oncology Associates Incorporated | Hinsdale | Illinois | United States | 60521 |
| 196 | Presence Saint Mary's Hospital | Kankakee | Illinois | United States | 60901 |
| 197 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 198 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 199 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 200 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 201 | Garneau, Stewart C MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 202 | Porubcin, Michael MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 203 | Spector, David MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 204 | Trinity Medical Center | Moline | Illinois | United States | 61265 |
| 205 | Illinois CancerCare-Monmouth | Monmouth | Illinois | United States | 61462 |
| 206 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 207 | Community Cancer Center Foundation | Normal | Illinois | United States | 61761 |
| 208 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 209 | Radiation Oncology of Northern Illinois | Ottawa | Illinois | United States | 61350 |
| 210 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 211 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 212 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 213 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 214 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 215 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 216 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 217 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 218 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 219 | West Suburban Medical Center | River Forest | Illinois | United States | 60305 |
| 220 | SwedishAmerican Regional Cancer Center/ACT | Rockford | Illinois | United States | 61114 |
| 221 | North Shore Medical Center | Skokie | Illinois | United States | 60076 |
| 222 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
| 223 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 224 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 225 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 226 | Cancer Care Specialists of Illinois-Swansea | Swansea | Illinois | United States | 62226 |
| 227 | Southwest Illinois Health Services LLP | Swansea | Illinois | United States | 62226 |
| 228 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 229 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 230 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 231 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 232 | IU Health Bloomington | Bloomington | Indiana | United States | 47403 |
| 233 | Deaconess Clinic Downtown | Evansville | Indiana | United States | 47713 |
| 234 | Fort Wayne Medical Oncology and Hematology Inc - Jefferson Boulevard | Fort Wayne | Indiana | United States | 46804 |
| 235 | Parkview Hospital Randallia | Fort Wayne | Indiana | United States | 46805 |
| 236 | Fort Wayne Medical Oncology and Hematology Inc-Parkview | Fort Wayne | Indiana | United States | 46845 |
| 237 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
| 238 | Springmill Medical Center | Indianapolis | Indiana | United States | 46290 |
| 239 | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | United States | 46360 |
| 240 | Woodland Cancer Care Center | Michigan City | Indiana | United States | 46360 |
| 241 | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana | United States | 46545 |
| 242 | IU Health Ball Memorial Hospital | Muncie | Indiana | United States | 47303 |
| 243 | The Community Hospital | Munster | Indiana | United States | 46321 |
| 244 | Chancellor Center for Oncology | Newburgh | Indiana | United States | 47630 |
| 245 | Reid Health | Richmond | Indiana | United States | 47374 |
| 246 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 247 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 248 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 249 | Constantinou, Costas L MD (UIA Investigator) | Bettendorf | Iowa | United States | 52722 |
| 250 | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 251 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 252 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 253 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 254 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 255 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 256 | Alegent Health Mercy Hospital | Council Bluffs | Iowa | United States | 51503 |
| 257 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 258 | Genesis Medical Center - East Campus | Davenport | Iowa | United States | 52803 |
| 259 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 260 | Iowa-Wide Oncology Research Coalition NCORP | Des Moines | Iowa | United States | 50309 |
| 261 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 262 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 263 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 264 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 265 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 266 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 267 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 268 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 269 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 270 | Siouxland Regional Cancer Center | Sioux City | Iowa | United States | 51101 |
| 271 | Mercy Medical Center-Sioux City | Sioux City | Iowa | United States | 51104 |
| 272 | Saint Luke's Regional Medical Center | Sioux City | Iowa | United States | 51104 |
| 273 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 274 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 275 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 276 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 277 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 278 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 279 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 280 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 281 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 282 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 283 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 284 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 285 | Minimally Invasive Surgery Hospital | Lenexa | Kansas | United States | 66219 |
| 286 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 287 | Cancer Center of Kansas-Manhattan | Manhattan | Kansas | United States | 66502 |
| 288 | Cancer Center of Kansas - McPherson | McPherson | Kansas | United States | 67460 |
| 289 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 290 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 291 | Saint Luke's South Hospital | Overland Park | Kansas | United States | 66213 |
| 292 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 293 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 294 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 295 | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | United States | 66606 |
| 296 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 297 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 298 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 299 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 300 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
| 301 | Wichita NCI Community Oncology Research Program | Wichita | Kansas | United States | 67214 |
| 302 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 303 | Flaget Memorial Hospital | Bardstown | Kentucky | United States | 40004 |
| 304 | Commonwealth Cancer Center-Corbin | Corbin | Kentucky | United States | 40701 |
| 305 | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky | United States | 41017 |
| 306 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 307 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 308 | Saint Joseph London | London | Kentucky | United States | 40741 |
| 309 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 310 | Saints Mary and Elizabeth Hospital | Louisville | Kentucky | United States | 40215 |
| 311 | Jewish Hospital Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 312 | Jewish Hospital Medical Center South | Shepherdsville | Kentucky | United States | 40165 |
| 313 | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 314 | Baton Rouge General Medical Center | Baton Rouge | Louisiana | United States | 70806 |
| 315 | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | United States | 70809 |
| 316 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 317 | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | United States | 70809 |
| 318 | Mary Bird Cancer Center/Saint Tammany Parish | Covington | Louisiana | United States | 70433 |
| 319 | Northshore Oncology Associates-Covington | Covington | Louisiana | United States | 70433 |
| 320 | Mary Bird Perkins Cancer Center/Terrebonne General Medical Center | Houma | Louisiana | United States | 70360 |
| 321 | Oncology Center of The South Incorporated | Houma | Louisiana | United States | 70360 |
| 322 | University Health-Conway | Monroe | Louisiana | United States | 71202 |
| 323 | Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana | United States | 71103 |
| 324 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 325 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 326 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 327 | Central Maine Medical Center | Lewiston | Maine | United States | 04240 |
| 328 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 329 | York Hospital | York | Maine | United States | 03909 |
| 330 | MedStar Union Memorial Hospital | Baltimore | Maryland | United States | 21218 |
| 331 | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | United States | 21237 |
| 332 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 333 | Frederick Memorial Hospital | Frederick | Maryland | United States | 21701 |
| 334 | Tufts Medical Center | Boston | Massachusetts | United States | 02111 |
| 335 | Lowell General Hospital | Lowell | Massachusetts | United States | 01854 |
| 336 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 337 | Bixby Medical Center | Adrian | Michigan | United States | 49221 |
| 338 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 339 | Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | United States | 48106 |
| 340 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 341 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 342 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 343 | McLaren Cancer Institute-Bay City | Bay City | Michigan | United States | 48706 |
| 344 | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan | United States | 48114 |
| 345 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 346 | Henry Ford Cancer Institute?Downriver | Brownstown | Michigan | United States | 48183 |
| 347 | IHA Hematology Oncology Consultants-Canton | Canton | Michigan | United States | 48188 |
| 348 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 349 | Caro Cancer Center | Caro | Michigan | United States | 48723 |
| 350 | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan | United States | 48118 |
| 351 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 352 | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | United States | 48346 |
| 353 | McLaren Cancer Institute-Clarkston | Clarkston | Michigan | United States | 48346 |
| 354 | Newland Medical Associates-Clarkston | Clarkston | Michigan | United States | 48346 |
| 355 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 356 | Huron Valley-Sinai Hospital | Commerce | Michigan | United States | 48382 |
| 357 | Beaumont Hospital-Dearborn | Dearborn | Michigan | United States | 48124 |
| 358 | Henry Ford Medical Center-Fairlane | Dearborn | Michigan | United States | 48126 |
| 359 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 360 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 361 | Saint John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
| 362 | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan | United States | 48054 |
| 363 | Michigan State University Clinical Center | East Lansing | Michigan | United States | 48824-7016 |
| 364 | Green Bay Oncology - Escanaba | Escanaba | Michigan | United States | 49829 |
| 365 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 366 | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan | United States | 48336 |
| 367 | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan | United States | 48503 |
| 368 | Genesee Hematology Oncology PC | Flint | Michigan | United States | 48503 |
| 369 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 370 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 371 | Singh and Arora Hematology Oncology PC | Flint | Michigan | United States | 48532 |
| 372 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 373 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 374 | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 375 | Lymphoma Clinic of Michigan | Grosse Pointe Woods | Michigan | United States | 48236 |
| 376 | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan | United States | 48236 |
| 377 | William Beaumont Hospital-Grosse Point | Grosse Pointe | Michigan | United States | 48230 |
| 378 | Green Bay Oncology - Iron Mountain | Iron Mountain | Michigan | United States | 49801 |
| 379 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 380 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 381 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 382 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 383 | McLaren-Greater Lansing | Lansing | Michigan | United States | 48910 |
| 384 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 385 | McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | United States | 48446 |
| 386 | Hope Cancer Clinic | Livonia | Michigan | United States | 48154 |
| 387 | Saint Mary Mercy Hospital | Livonia | Michigan | United States | 48154 |
| 388 | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan | United States | 48044 |
| 389 | Michigan Breast Specialists-Macomb Township | Macomb | Michigan | United States | 48044 |
| 390 | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | United States | 48453 |
| 391 | Mid-Michigan Medical Center - Midland | Midland | Michigan | United States | 48670 |
| 392 | Mercy Memorial Hospital | Monroe | Michigan | United States | 48162 |
| 393 | Monroe Cancer Center | Monroe | Michigan | United States | 48162 |
| 394 | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | United States | 48162 |
| 395 | McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | United States | 48858 |
| 396 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 397 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 398 | Assarian Cancer Center | Novi | Michigan | United States | 48374-1236 |
| 399 | Henry Ford Medical Center-Columbus | Novi | Michigan | United States | 48377 |
| 400 | McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | United States | 49770 |
| 401 | 21st Century Oncology-Pontiac | Pontiac | Michigan | United States | 48341 |
| 402 | Hope Cancer Center | Pontiac | Michigan | United States | 48341 |
| 403 | Newland Medical Associates-Pontiac | Pontiac | Michigan | United States | 48341 |
| 404 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 405 | Huron Medical Center PC | Port Huron | Michigan | United States | 48060 |
| 406 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 407 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 408 | Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan | United States | 48309 |
| 409 | Michigan Cancer Specialists | Roseville | Michigan | United States | 48066 |
| 410 | Oakland Colon and Rectal Association | Royal Oak | Michigan | United States | 48067 |
| 411 | Cancer Care Associates PC | Royal Oak | Michigan | United States | 48073 |
| 412 | Comprehensive Medical Center PLLC | Royal Oak | Michigan | United States | 48073 |
| 413 | Hematology Oncology Consultants PC | Royal Oak | Michigan | United States | 48073 |
| 414 | Oakland Medical Group | Royal Oak | Michigan | United States | 48073 |
| 415 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 416 | Saint Mary's of Michigan | Saginaw | Michigan | United States | 48601 |
| 417 | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | United States | 48604 |
| 418 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 419 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 420 | Providence Hospital-Southfield Cancer Center | Southfield | Michigan | United States | 48075 |
| 421 | Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan | United States | 48312 |
| 422 | Premier Hematology Oncology Care | Sterling Heights | Michigan | United States | 48312 |
| 423 | Mitchell Folbe MD PC | Sterling Heights | Michigan | United States | 48314 |
| 424 | Saint Joseph Health System-Tawas City | Tawas City | Michigan | United States | 48764 |
| 425 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 426 | Michigan Institute of Urology-Town Center | Troy | Michigan | United States | 48084 |
| 427 | Claudia BR Herke MD PC | Troy | Michigan | United States | 48085 |
| 428 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 429 | Hematology Oncology Consultants PC-Troy | Troy | Michigan | United States | 48098 |
| 430 | Advanced Breast Care Center PLLC | Warren | Michigan | United States | 48088 |
| 431 | Bhadresh Nayak MD PC-Warren | Warren | Michigan | United States | 48093 |
| 432 | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan | United States | 48093 |
| 433 | Macomb Hematology Oncology PC | Warren | Michigan | United States | 48093 |
| 434 | Michigan Breast Specialists-Warren | Warren | Michigan | United States | 48093 |
| 435 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 436 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 437 | Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | United States | 48661 |
| 438 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 439 | Huron Gastroenterology PC | Ypsilanti | Michigan | United States | 48106 |
| 440 | IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | United States | 48197 |
| 441 | Sanford Clinic North-Bemidgi | Bemidji | Minnesota | United States | 56601 |
| 442 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 443 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 444 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 445 | Essentia Health - Deer River Clinic | Deer River | Minnesota | United States | 56636 |
| 446 | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota | United States | 56501 |
| 447 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 448 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 449 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 450 | Fairview-Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 451 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 452 | Essentia Health - Fosston | Fosston | Minnesota | United States | 56542 |
| 453 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 454 | Essentia Health Hibbing Clinic | Hibbing | Minnesota | United States | 55746 |
| 455 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 456 | Fairview Maple Grove Medical Center | Maple Grove | Minnesota | United States | 55369 |
| 457 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 458 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 459 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 460 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 461 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 462 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 463 | Essentia Health - Park Rapids | Park Rapids | Minnesota | United States | 56470 |
| 464 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 465 | Mayo Clinic | Rochester | Minnesota | United States | 55905 |
| 466 | Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | United States | 55416 |
| 467 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 468 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 469 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 470 | Essentia Health Sandstone | Sandstone | Minnesota | United States | 55072 |
| 471 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 472 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 473 | Essentia Health Virginia Clinic | Virginia | Minnesota | United States | 55792 |
| 474 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 475 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 476 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 477 | Sanford Cancer Center Worthington | Worthington | Minnesota | United States | 56187 |
| 478 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 479 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 480 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 481 | Cox Cancer Center Branson | Branson | Missouri | United States | 65616 |
| 482 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 483 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 484 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 485 | University of Missouri - Ellis Fischel | Columbia | Missouri | United States | 65212 |
| 486 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 487 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 488 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 489 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 490 | Saint Luke's Hospital of Kansas City | Kansas City | Missouri | United States | 64111 |
| 491 | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | United States | 64128 |
| 492 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 493 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 494 | Liberty Radiation Oncology Center | Liberty | Missouri | United States | 64068 |
| 495 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 496 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 497 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64507 |
| 498 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 499 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 500 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 501 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 502 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 503 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 504 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 505 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 506 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 507 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 508 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 509 | Montana Cancer Consortium NCORP | Billings | Montana | United States | 59102 |
| 510 | Saint Vincent Frontier Cancer Center | Billings | Montana | United States | 59102 |
| 511 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 512 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 513 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 514 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 515 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 516 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 517 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 518 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 519 | Nebraska Medicine-Bellevue | Bellevue | Nebraska | United States | 68123 |
| 520 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 521 | Heartland Hematology and Oncology | Kearney | Nebraska | United States | 68845 |
| 522 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 523 | Nebraska Hematology and Oncology | Lincoln | Nebraska | United States | 68506 |
| 524 | Nebraska Cancer Research Center | Lincoln | Nebraska | United States | 68510 |
| 525 | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | United States | 68510 |
| 526 | Southeast Nebraska Cancer Center | Lincoln | Nebraska | United States | 68510 |
| 527 | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska | United States | 68701 |
| 528 | Great Plains Health Callahan Cancer Center | North Platte | Nebraska | United States | 69101 |
| 529 | Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 530 | Nebraska Medicine-Village Pointe | Omaha | Nebraska | United States | 68118 |
| 531 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 532 | Hematology and Oncology Consultants PC | Omaha | Nebraska | United States | 68122 |
| 533 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 534 | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska | United States | 68124 |
| 535 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 536 | Oncology Hematology West PC | Omaha | Nebraska | United States | 68130 |
| 537 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 538 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 539 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 540 | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska | United States | 69361 |
| 541 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 542 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 543 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 544 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 545 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 546 | Nevada Cancer Specialists-Saint Rose | Henderson | Nevada | United States | 89052 |
| 547 | 21st Century Oncology-Henderson | Henderson | Nevada | United States | 89074 |
| 548 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 549 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 550 | Nevada Cancer Specialists?Oakey | Las Vegas | Nevada | United States | 89102 |
| 551 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 552 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
| 553 | Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | United States | 89106 |
| 554 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 555 | 21st Century Oncology | Las Vegas | Nevada | United States | 89109 |
| 556 | Children's Specialty Center of Nevada II | Las Vegas | Nevada | United States | 89109 |
| 557 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 558 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 559 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 560 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
| 561 | 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 562 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 563 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 564 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 565 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 566 | Nevada Cancer Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 567 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 568 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 569 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 570 | 21st Century Oncology-Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 571 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 572 | Nevada Cancer Specialists-Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 573 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 574 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 575 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 576 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 577 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 578 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 579 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 580 | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | United States | 03301 |
| 581 | Wentworth-Douglass Hospital | Dover | New Hampshire | United States | 03820 |
| 582 | New Hampshire Oncology Hematology PA-Hooksett | Hooksett | New Hampshire | United States | 03106 |
| 583 | Veterans Adminstration New Jersey Health Care System | East Orange | New Jersey | United States | 07018-1095 |
| 584 | The Cancer Institute of New Jersey Hamilton | Hamilton | New Jersey | United States | 08690 |
| 585 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 586 | Virtua Memorial | Mount Holly | New Jersey | United States | 08060 |
| 587 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 588 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 589 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 590 | Inspira Medical Center Vineland | Vineland | New Jersey | United States | 08360 |
| 591 | Virtua Voorhees | Voorhees | New Jersey | United States | 08043 |
| 592 | Inspira Medical Center Woodbury | Woodbury | New Jersey | United States | 08096 |
| 593 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 594 | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico | United States | 88011 |
| 595 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
| 596 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
| 597 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 598 | Kings County Hospital | Brooklyn | New York | United States | 11203 |
| 599 | State University of New York Downstate Medical Center | Brooklyn | New York | United States | 11203 |
| 600 | Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326 |
| 601 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 602 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 603 | Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | United States | 12901 |
| 604 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 605 | Randolph Hospital | Asheboro | North Carolina | United States | 27203 |
| 606 | Mission Hospital Inc-Memorial Campus | Asheville | North Carolina | United States | 28801 |
| 607 | Asheville Hematology-Oncology Associates | Asheville | North Carolina | United States | 28803 |
| 608 | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina | United States | 27215 |
| 609 | Sampson Radiation Oncology | Clinton | North Carolina | United States | 28328 |
| 610 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 611 | Haywood Infusion Center | Clyde | North Carolina | United States | 28721 |
| 612 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 613 | Wayne Memorial Hospital | Goldsboro | North Carolina | United States | 27534 |
| 614 | Wayne Radiation Oncology | Goldsboro | North Carolina | United States | 27534 |
| 615 | Cone Health Cancer Center | Greensboro | North Carolina | United States | 27403 |
| 616 | East Carolina University | Greenville | North Carolina | United States | 27858 |
| 617 | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina | United States | 28791 |
| 618 | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 619 | Park Ridge Health | Hendersonville | North Carolina | United States | 28792 |
| 620 | Onslow Memorial Hospital | Jacksonville | North Carolina | United States | 28546 |
| 621 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 622 | Vidant Oncology-Kinston | Kinston | North Carolina | United States | 28501 |
| 623 | Cone Heath Cancer Center at Mebane | Mebane | North Carolina | United States | 27302 |
| 624 | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | United States | 28374 |
| 625 | Annie Penn Memorial Hospital | Reidsville | North Carolina | United States | 27320 |
| 626 | Iredell Memorial Hospital | Statesville | North Carolina | United States | 28677 |
| 627 | Southeastern Medical Oncology Center-Wilson | Wilson | North Carolina | United States | 27893 |
| 628 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 629 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 630 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
| 631 | Sanford South University Medical Center | Fargo | North Dakota | United States | 58103 |
| 632 | Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 633 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 634 | Sanford Clinic North-Fargo | Fargo | North Dakota | United States | 58122 |
| 635 | Essentia Health - Jamestown Clinic | Jamestown | North Dakota | United States | 58401 |
| 636 | Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | United States | 44304 |
| 637 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 638 | Strecker Cancer Center-Belpre | Belpre | Ohio | United States | 45714 |
| 639 | Toledo Clinic Cancer Centers-Bowling Green | Bowling Green | Ohio | United States | 43402 |
| 640 | Mercy Medical Center | Canton | Ohio | United States | 44708 |
| 641 | Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 642 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 643 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 644 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 645 | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio | United States | 45202 |
| 646 | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio | United States | 45211 |
| 647 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 648 | Oncology Hematology Care Inc - Anderson | Cincinnati | Ohio | United States | 45230 |
| 649 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 650 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 651 | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | United States | 45242 |
| 652 | TriHealth Cancer Institute-Westside | Cincinnati | Ohio | United States | 45247 |
| 653 | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | United States | 45255 |
| 654 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 655 | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | United States | 43214 |
| 656 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 657 | Columbus NCI Community Oncology Research Program | Columbus | Ohio | United States | 43215 |
| 658 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 659 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 660 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 661 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 662 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 663 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 664 | Dayton Physicians LLC-Samaritan North | Dayton | Ohio | United States | 45415 |
| 665 | Samaritan North Health Center | Dayton | Ohio | United States | 45415 |
| 666 | Dayton NCI Community Oncology Research Program | Dayton | Ohio | United States | 45420 |
| 667 | Veteran Affairs Medical Center | Dayton | Ohio | United States | 45428 |
| 668 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 669 | Delaware Radiation Oncology | Delaware | Ohio | United States | 43015 |
| 670 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 671 | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio | United States | 45014 |
| 672 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 673 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 674 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 675 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 676 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 677 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 678 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 679 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 680 | First Dayton Cancer Care | Kettering | Ohio | United States | 45420 |
| 681 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 682 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 683 | Lancaster Radiation Oncology | Lancaster | Ohio | United States | 43130 |
| 684 | Saint Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 685 | Lima Memorial Hospital | Lima | Ohio | United States | 45804 |
| 686 | OhioHealth Mansfield Hospital | Mansfield | Ohio | United States | 44903 |
| 687 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 688 | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | United States | 43537 |
| 689 | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio | United States | 43537 |
| 690 | Dayton Physicians LLC-Signal Point | Middletown | Ohio | United States | 45042 |
| 691 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 692 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 693 | Newark Radiation Oncology | Newark | Ohio | United States | 43055 |
| 694 | Saint Charles Hospital | Oregon | Ohio | United States | 43616 |
| 695 | Toledo Clinic Cancer Centers-Oregon | Oregon | Ohio | United States | 43616 |
| 696 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 697 | Dayton Physicians LLC-Wilson | Sidney | Ohio | United States | 45365 |
| 698 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 699 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 700 | Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 701 | Mercy Hospital of Tiffin | Tiffin | Ohio | United States | 44883 |
| 702 | The Toledo Hospital/Toledo Children's Hospital | Toledo | Ohio | United States | 43606 |
| 703 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 704 | University of Toledo | Toledo | Ohio | United States | 43614 |
| 705 | Toledo Community Hospital Oncology Program CCOP | Toledo | Ohio | United States | 43617 |
| 706 | Mercy Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 707 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 708 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 709 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 710 | Fulton County Health Center | Wauseon | Ohio | United States | 43567 |
| 711 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 712 | Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | United States | 45433-5529 |
| 713 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 714 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 715 | Integris Southwest Medical Center | Oklahoma City | Oklahoma | United States | 73109 |
| 716 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 717 | Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | United States | 74146 |
| 718 | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | United States | 97814 |
| 719 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 720 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 721 | Providence Oncology and Hematology Care Southeast | Clackamas | Oregon | United States | 97015 |
| 722 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 723 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 724 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 725 | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | United States | 97914 |
| 726 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 727 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 728 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 729 | Oregon Health and Science University | Portland | Oregon | United States | 97239 |
| 730 | Saint Charles Health System-Redmond | Redmond | Oregon | United States | 97756 |
| 731 | Legacy Meridian Park Hospital | Tualatin | Oregon | United States | 97062 |
| 732 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 733 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 734 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 735 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 736 | Ephrata Cancer Center | Ephrata | Pennsylvania | United States | 17522 |
| 737 | Ephrata Community Hospital | Ephrata | Pennsylvania | United States | 17522 |
| 738 | Adams Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 739 | Cherry Tree Cancer Center | Hanover | Pennsylvania | United States | 17331 |
| 740 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 741 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 742 | Sechler Family Cancer Center | Lebanon | Pennsylvania | United States | 17042 |
| 743 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 744 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 745 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 746 | Temple University Hospital | Philadelphia | Pennsylvania | United States | 19140 |
| 747 | Phoenixville Hospital | Phoenixville | Pennsylvania | United States | 19460 |
| 748 | Pottstown Hospital | Pottstown | Pennsylvania | United States | 19464 |
| 749 | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 750 | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania | United States | 19605 |
| 751 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 752 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 753 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 754 | Chester County Hospital | West Chester | Pennsylvania | United States | 19380 |
| 755 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 756 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 757 | UPMC Susquehanna | Williamsport | Pennsylvania | United States | 17701 |
| 758 | WellSpan Health-York Cancer Center | York | Pennsylvania | United States | 17403 |
| 759 | WellSpan Health-York Hospital | York | Pennsylvania | United States | 17403 |
| 760 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 761 | Greenville Health System Cancer Institute-Easley | Easley | South Carolina | United States | 29640 |
| 762 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 763 | Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | United States | 29440 |
| 764 | Greenville Health System Cancer Institute-Andrews | Greenville | South Carolina | United States | 29601 |
| 765 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 766 | Greenville Health System Cancer Institute-Butternut | Greenville | South Carolina | United States | 29605 |
| 767 | Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | United States | 29605 |
| 768 | Greenville Memorial Hospital | Greenville | South Carolina | United States | 29605 |
| 769 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 770 | Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | United States | 29615 |
| 771 | Greenville Health System Cancer Institute-Greer | Greer | South Carolina | United States | 29650 |
| 772 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 773 | South Carolina Cancer Specialists PC | Hilton Head Island | South Carolina | United States | 29926-3827 |
| 774 | Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina | United States | 29672 |
| 775 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 776 | Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | United States | 29307 |
| 777 | MGC Hematology Oncology-Union | Union | South Carolina | United States | 29379 |
| 778 | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 779 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 780 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 781 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 782 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 783 | Memorial Hospital | Chattanooga | Tennessee | United States | 37404 |
| 784 | Cookeville Regional Medical Center | Cookeville | Tennessee | United States | 38501 |
| 785 | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee | United States | 37343 |
| 786 | Meharry Medical College | Nashville | Tennessee | United States | 37208 |
| 787 | Memorial GYN Plus | Ooltewah | Tennessee | United States | 37363 |
| 788 | Hendrick Medical Center | Abilene | Texas | United States | 79601 |
| 789 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 790 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 791 | Ben Taub General Hospital | Houston | Texas | United States | 77030 |
| 792 | Michael E DeBakey VA Medical Center | Houston | Texas | United States | 77030 |
| 793 | Cancer Therapy and Research Center at The UT Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 794 | University Hospital | San Antonio | Texas | United States | 78229 |
| 795 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 796 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 797 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 798 | University of Vermont College of Medicine | Burlington | Vermont | United States | 05405 |
| 799 | University of Virginia Cancer Center | Charlottesville | Virginia | United States | 22908 |
| 800 | Fredericksburg Oncology Inc | Fredericksburg | Virginia | United States | 22401 |
| 801 | Hematology Oncology Associates of Fredericksburg Inc | Fredericksburg | Virginia | United States | 22408 |
| 802 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 803 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 804 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 805 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 806 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 807 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 808 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 809 | Swedish Medical Center-Edmonds | Edmonds | Washington | United States | 98026 |
| 810 | Saint Elizabeth Hospital | Enumclaw | Washington | United States | 98022 |
| 811 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 812 | Saint Francis Hospital | Federal Way | Washington | United States | 98003 |
| 813 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 814 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 815 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 816 | Saint Clare Hospital | Lakewood | Washington | United States | 98499 |
| 817 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 818 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 819 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 820 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 821 | Kaiser Permanente Washington | Seattle | Washington | United States | 98112 |
| 822 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 823 | Swedish Medical Center-Cherry Hill | Seattle | Washington | United States | 98122-5711 |
| 824 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 825 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 826 | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | United States | 98405 |
| 827 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 828 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 829 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 830 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 831 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 832 | United Hospital Center | Bridgeport | West Virginia | United States | 26330 |
| 833 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 834 | WVUH-Berkely Medical Center | Martinsburg | West Virginia | United States | 25401 |
| 835 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 836 | Camden Clark Medical Center | Parkersburg | West Virginia | United States | 26101 |
| 837 | Langlade Hospital and Cancer Center | Antigo | Wisconsin | United States | 54409 |
| 838 | Ashland Memorial Medical Center | Ashland | Wisconsin | United States | 54806 |
| 839 | Duluth Clinic Ashland | Ashland | Wisconsin | United States | 54806 |
| 840 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 841 | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
| 842 | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin | United States | 54701 |
| 843 | Marshfield Clinic Cancer Center - Eau Claire | Eau Claire | Wisconsin | United States | 54701 |
| 844 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
| 845 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
| 846 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 847 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 848 | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | United States | 54301-3526 |
| 849 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
| 850 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 851 | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 852 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 853 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 854 | Mercy Health System | Janesville | Wisconsin | United States | 53547 |
| 855 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 856 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 857 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 858 | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin | United States | 54848 |
| 859 | William S Middleton VA Medical Center | Madison | Wisconsin | United States | 53705 |
| 860 | Dean Hematology and Oncology Clinic | Madison | Wisconsin | United States | 53717 |
| 861 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792 |
| 862 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54221 |
| 863 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 864 | Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 865 | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin | United States | 54143 |
| 866 | Vince Lombardi Cancer Clinic-Marinette | Marinette | Wisconsin | United States | 54143 |
| 867 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 868 | Marshfield Medical Center | Marshfield | Wisconsin | United States | 54449 |
| 869 | Columbia Saint Mary's Hospital - Ozaukee | Mequon | Wisconsin | United States | 53097 |
| 870 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 871 | Columbia Saint Mary's Water Tower Medical Commons | Milwaukee | Wisconsin | United States | 53211 |
| 872 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 873 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 874 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 875 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 876 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 877 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 878 | Green Bay Oncology - Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 879 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 880 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 881 | Ascension Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 882 | Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 883 | Marshfield Clinic-Rice Lake Center | Rice Lake | Wisconsin | United States | 54868 |
| 884 | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 885 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 886 | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 887 | Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 888 | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | United States | 54482 |
| 889 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
| 890 | Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 891 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 892 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 893 | Aurora Cancer Care-Waukesha | Waukesha | Wisconsin | United States | 53188 |
| 894 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 895 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 896 | Aspirus Regional Cancer Center | Wausau | Wisconsin | United States | 54401 |
| 897 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 898 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 899 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 900 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 901 | Marshfield Clinic - Weston Center | Weston | Wisconsin | United States | 54476 |
| 902 | Saint Clare's Hospital | Weston | Wisconsin | United States | 54476 |
| 903 | Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 904 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 905 | Rocky Mountain Oncology | Casper | Wyoming | United States | 82609 |
| 906 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 907 | Big Horn Basin Cancer Center | Cody | Wyoming | United States | 82414 |
| 908 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 909 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 910 | Advance Oncology Center | Aguadilla | Puerto Rico | 00603 | |
| 911 | Doctor's Cancer Center-Arecibo | Arecibo | Puerto Rico | 00614 | |
| 912 | Cancer Center-Metro Medical Center Bayamon | Bayamon | Puerto Rico | 00959-5060 | |
| 913 | Hematologia Oncologia San Pablo | Bayamon | Puerto Rico | 00961 | |
| 914 | HIMA San Pablo Oncologic Hospital | Caguas | Puerto Rico | 00726 | |
| 915 | Doctors Cancer Center | Manati | Puerto Rico | 00674 | |
| 916 | Instituto Oncologia Moderna Ponce | Ponce | Puerto Rico | 00716 | |
| 917 | San Juan Community Oncology Group | San Juan | Puerto Rico | 00917 | |
| 918 | Primary Care Physician Group | San Juan | Puerto Rico | 00920 | |
| 919 | San Juan City Hospital | San Juan | Puerto Rico | 00936 | |
| 920 | Centro de Hematologia y Oncologia del Sur | Santa Isabel | Puerto Rico | 00757 |
Sponsors and Collaborators
- ECOG-ACRIN Cancer Research Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Shaji Kumar, ECOG-ACRIN Cancer Research Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- E1A11
- NCI-2012-02608
- ECOG-E1A11
- E1A11
- s17-00040
- E1A11
- E1A11
- U10CA180820
- U10CA021115
- U24CA196172