Effects of Plasmapheresis on Aging Biomarkers
Study Details
Study Description
Brief Summary
The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group 1 Group 1 consists of first time donors undergoing all 8 tracked plasmaphereses. |
Procedure: Plasmapheresis
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.
|
| Group 2 Group 2 consists of first time donors undergoing only last 4 plasmaphereses, serving as control for the first 4 donations. |
Procedure: Plasmapheresis
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.
|
Outcome Measures
Primary Outcome Measures
- Significant change of biological age according to epigenetic clock after 8 plasmaphereses [Through study completion, an average of 8 months]
Significant change of the epigenetic age of the plasma donors after 8 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.
Secondary Outcome Measures
- Significant change of biological age according to epigenetic clock after 8 plasmaphereses [Through study completion, an average of 8 months]
Significant change of the epigenetic age of the plasma donors after 4 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.
- Significant change of the proteomic profile after 8 plasmaphereses [Through study completion, an average of 8 months]
Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.
- Significant change of the proteomic profile after 4 plasmaphereses [Through study completion, an average of 8 months]
Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.
- Significant change of the biological age according to a blood biochemistry clock after 8 plasmaphereses [Through study completion, an average of 8 months]
Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.
- Significant change of the biological age according to a blood biochemistry clock after 4 plasmaphereses [Through study completion, an average of 8 months]
Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Generally healthy volunteer subjects age 40 - 60
-
50:50 man and woman
Exclusion Criteria:
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Subjects excluded from plasma donation protocols (serious illness, infection, etc)
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Subjects undergoing stronger anti-aging interventions
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Charles University, Medical Faculty in Hradec Kralove | Hradec Králové | Czechia |
Sponsors and Collaborators
- Charles University, Czech Republic
- University Hospital Hradec Kralove
- Longevitytech.fund a.s.
- Clock Foundation
- AGECURVE LIMITED
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 202103 P07