Platelet and Red Blood Cell Volume Indices as Inflammatory Biomarkers in Ankylosing Spondylitis

• Sponsor: Sohag University (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT05997108
• Collaborator: (none)
• Enrollment: 70
• Location: 1
• Anticipated Duration (Months): 6
• Patients Per Site Per Month: 11.6

Study Details

Study Description

Brief Summary

this study aims to determine the relatioships among the NLR ,PLR ,MLR ,red cell volume and platelet volume indices levels as biomarkers in ankylosing spondylitis.

Condition or Disease	Intervention/Treatment	Phase
Ankylosing Spondylitis	Diagnostic Test: CBC

Study Design

• Study Type: Observational
• Anticipated Enrollment: 70 participants
• Observational Model: Case-Control
• Time Perspective: Retrospective
• Official Title: Platelet and Red Blood Cell Volume Indices as Inflammatory Biomarkers in Ankylosing Spodylitis
• Actual Study Start Date: Aug 1, 2023
• Anticipated Primary Completion Date: Feb 1, 2024
• Anticipated Study Completion Date: Feb 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
cases group	Diagnostic Test: CBC; Platelet and red blood cell volume indices
control group	Diagnostic Test: CBC; Platelet and red blood cell volume indices

Outcome Measures

Primary Outcome Measures

1. platelet [6 months]

   platelet cell volume indices

2. Red blood cell [6 months]

   red blood cell volume indices

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 70 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• PATIENT WITH DISEASE DURATION OF MORE THAN 6 MONTHS

• AGE MORE THAN 18 YEARS

Exclusion Criteria:

• PATIENT WITH CARDIAC ,CEREBROVASCULAR AND HEMATOLOGIC DIEASE

• PTIENT WITH HYPERTENSION ,DIABETES ,METABOLIS SYNDROMES AND OTHER AUTOIMMUNE RHEUMATIC DISEASES.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Sohag university Hospital	Sohag		Egypt

Sponsors and Collaborators

• Sohag University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

• Azab B, Torbey E, Singh J, Akerman M, Khoueiry G, McGinn JT, Widmann WD, Lafferty J. Mean platelet volume/platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction. Platelets. 2011;22(8):557-66. doi: 10.3109/09537104.2011.584086. Epub 2011 Jun 30.
• Bekdas M, Goksugur SB, Sarac EG, Erkocoglu M, Demircioglu F. Neutrophil/lymphocyte and C-reactive protein/mean platelet volume ratios in differentiating between viral and bacterial pneumonias and diagnosing early complications in children. Saudi Med J. 2014 May;35(5):442-7.
• Coutant F, Miossec P. Evolving concepts of the pathogenesis of rheumatoid arthritis with focus on the early and late stages. Curr Opin Rheumatol. 2020 Jan;32(1):57-63. doi: 10.1097/BOR.0000000000000664.
• Kumano Y, Hasegawa Y, Kawahara T, Yasui M, Miyoshi Y, Matsubara N, Uemura H. Pretreatment Neutrophil to Lymphocyte Ratio (NLR) Predicts Prognosis for Castration Resistant Prostate Cancer Patients Underwent Enzalutamide. Biomed Res Int. 2019 Jan 20;2019:9450838. doi: 10.1155/2019/9450838. eCollection 2019.

• Responsible Party: Margo Gerges Mofeed, Resident-rheumatology department-sohag general hospital, Sohag University
• ClinicalTrials.gov Identifier: NCT05997108
• Other Study ID Numbers: Soh-Med-23-07-01MS
• First Posted: Aug 18, 2023
• Last Update Posted: Aug 18, 2023
• Last Verified: Aug 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Spondylitis; Spondylarthritis; Spondylitis, Ankylosing

Study Results

No Results Posted as of Aug 18, 2023