Effects of Immunonutrition in Patients With Pneumonia
Study Details
Study Description
Brief Summary
The project is a randomized controlled trial taking place in the North Zealand hospital in the city Hilleroed, Denmark.
The aim is to investigate the potential beneficial effects of immunonutrition containing fish oil, arginine and RNA, on the acute immune response in patients with pneumonia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Immunonutrition has a well-documented beneficial effect on surgical patients by strengthening the immune system and reducing the following: inflammation, the number of infections as well as hospitalization time. A study in operated patients demonstrated the benefit of immunonutrition by reducing unwanted inflammation, measured by the pro-inflammatory signalling protein, interleukin-6. The same study saw a smaller decrease in immune function (measured as the level of phagocytosis) in the group receiving immunonutrition than in the control group. This project will investigate whether similar effects can be detected in patients with pneumonia.
The project is being carried out in a collaboration between the University of Copenhagen, The main hospital of Copenhagen (Rigshospitalet) and North Zealand Hospital. The project is a randomized clinical intervention study, which spans 10 days. Participants are allocated to the intervention group or the control group. The project is being carried out at the North Zealand hospital, at the Department of Pulmonary- and Infectious Diseases.
The intervention group receives the department's standard treatment (Standard Of Care) + immunonutrition, while the control group receives the hospital department's standard treatment (Standard Of Care). On a daily basis, the patient's clinical condition and the activity of the immune system is measured for the purpose of determine whether there is an effect of immunonutrition.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Intervention group The intervention group is receiving a nutritional drink containing potential immune stimulating ingredients (fish oil, arginine, nucleotides) |
Dietary Supplement: Oral Impact powder
Oral nutritional supplement containing fish oil, arginine and RNA
|
| No Intervention: Control group The Control group is receiving the hospital´s Standard Of Care. |
Outcome Measures
Primary Outcome Measures
- Interleukin-6 [daily measure from first day of inclusion until discharge (maximum 10 days)]
Measure of the acute immune response
Secondary Outcome Measures
- Length of stay [From admittance to discharge (maximum 10 days)]
Measure of hospitalized days
- Hand grip strength [Daily from admittance to discharge (maximum 10 days)]
Measure of the mobilization of strength
Eligibility Criteria
Criteria
Inclusion Criteria:
- Authorized individuals diagnosed with pneumonia who speak and write in danish
Exclusion Criteria:
-
individuals with Immunodeficiency
-
individuals with another primary diagnose
-
individuals with an allergy against product ingredients
-
individuals with dementia
-
individuals with dysphagia
-
individuals with cancer in treatment
-
individuals with Chronic Obstructive Pulmonary Disease on continuing steroid treatment or home administered oxygen treatment
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Lung Medicine and Infectious Diseases | Hillerød | Denmark | 3400 |
Sponsors and Collaborators
- University of Copenhagen
Investigators
- Principal Investigator: Birgitte L Madsen, M.D., Ph.D., North Zealand Hospital, Hilleroed, Denmark
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H-19088763