A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

• Sponsor: LyphoMed (Industry)
• Overall Status: Completed
• CT.gov ID: NCT00002292
• Collaborator: (none)
• Location: 1

Study Details

Study Description

Brief Summary

To compare parenteral versus inhaled pentamidine in patients with documented Pneumocystis carinii pneumonia (PCP) with AIDS.

Condition or Disease	Intervention/Treatment	Phase
Pneumonia, Pneumocystis Carinii; HIV Infections	Drug: Pentamidine isethionate	N/A

Study Design

• Study Type: Interventional
• Allocation: Randomized
• Primary Purpose: Treatment
• Official Title: Inhaled Versus Intravenous Pentamidine in Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Previous history of adverse reaction to pentamidine.

• History of asthma.

• Pulmonary Kaposi's sarcoma.

Patients with the following are excluded:

• Previous history of adverse reaction to pentamidine.

• History of asthma.

• Pulmonary Kaposi's sarcoma.

• Inability to understand the consent procedure.

All patients hospitalized at Cedars-Sinai Medical Center with AIDS and possible Pneumocystis carinii pneumonia (PCP) will be eligible.

• Patients with HIV antibody or AIDS and a clinical presentation suggesting PCP are eligible.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	LyphoMed Inc	Rosemont	Illinois	United States	60018

Sponsors and Collaborators

• LyphoMed

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

• Conte JE Jr, Chernoff D, Feigal DW Jr, Joseph P, McDonald C, Golden JA. Intravenous or inhaled pentamidine for treating Pneumocystis carinii pneumonia in AIDS. A randomized trial. Ann Intern Med. 1990 Aug 1;113(3):203-9.
• Soo Hoo GW, Mohsenifar Z, Meyer RD. Inhaled or intravenous pentamidine therapy for Pneumocystis carinii pneumonia in AIDS. A randomized trial. Ann Intern Med. 1990 Aug 1;113(3):195-202. Erratum in: Ann Intern Med 1990 Oct 1;113(7):561.

• ClinicalTrials.gov Identifier: NCT00002292
• Other Study ID Numbers: 023B; 88-001
• First Posted: Aug 31, 2001
• Last Update Posted: Jun 24, 2005
• Last Verified: Aug 1, 1989

• Keywords provided by , ,: AIDS-Related Opportunistic Infections; Pneumonia, Pneumocystis carinii; Pentamidine; Injections, Intravenous; Administration, Inhalation; Aerosols; Acquired Immunodeficiency Syndrome
• Additional relevant MeSH terms: Pneumonia; Acquired Immunodeficiency Syndrome; Pneumonia, Pneumocystis; Pentamidine

Study Results

No Results Posted as of Jun 24, 2005