Evolution of Pulmonary Ultrasound in Patients Hospitalized for Covid (Coronavirus Disease) 19

Sponsor
Centre Hospitalier Intercommunal Creteil (Other)
Overall Status
Completed
CT.gov ID
NCT04341766
Collaborator
(none)
106
17
3
6.2
2.1

Study Details

Study Description

Brief Summary

Clinical thoracic ultrasound plays an important role in the exploration, diagnosis and follow-up of thoracic pathologies.

The COVID (Coronavirus Disease) epidemic is leading to a large influx of patients in the emergency department with respiratory disorders. The rapid diagnosis of respiratory disorders in infected patients is important for further management.

Chest ultrasound has already demonstrated its value in the diagnosis of pneumonia in the emergency department with superiority over chest X-ray.

However, there is little data on the thoracic ultrasound semiology of viral pneumonia in general and of COVID in particular.

Condition or Disease Intervention/Treatment Phase
  • Other: No special intervention

Detailed Description

Chest ultrasound has already shown its value in the diagnosis of pneumonia in the emergency department with superiority over chest X-ray.

However, there is little data on the thoracic ultrasound semiology of viral pneumonia in general and of COVID in particular.

Peng reported data from 20 patients and compared them to chest CT. The abnormalities are a thickening of the pleuropneumonia line, an interstitial syndrome with B lines, corresponding to frosted glass opacities, confluent B lines (snowstorm appearance) corresponding to interstitial infiltrate, sub-pleural alveolar opacities corresponding to sub-pleural condensations, more frank alveolar images corresponding to alveolar opacities. A multifocal aspect was associated with involvement of more than 2 lobes. However, the frequency of these abnormalities as well as the sensitivity of the echo are not detailed in this article.

Another Italian article describes a clinical case of COVID-19 pneumonia with sub-pleural involvement and irregularity of the pleuro-pulmonary line.

Clinical thoracic ultrasound has a major potential interest during the COVID epidemic:

available at the patient's bedside, avoiding the need to move around, feasible for the physician during his visit, easy to clean especially if ultraportable devices are used, fast and not exposing the staff any more than the usual clinical examination.

In order to determine whether this technique is useful in the management of infected patients or patients suspected of COVID-19 infection with respiratory signs, we propose a descriptive prospective study evaluating the ultrasound semiology of COVID-19 pneumonia and the interest of ultrasound in the evolutionary follow-up of these patients.

Study Design

Study Type:
Observational [Patient Registry]
Actual Enrollment :
106 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Prospective Descriptive Study on the Evolution of Pulmonary Ultrasound in Patients Hospitalized for Covid19
Actual Study Start Date :
Mar 31, 2020
Actual Primary Completion Date :
May 27, 2020
Actual Study Completion Date :
Jun 30, 2020

Arms and Interventions

Arm Intervention/Treatment
Patient hospitalised with COVID-19 infection

Patients admitted to hospital with proven COVID-19 infection with respiratory signs warranting a chest CT scan

Other: No special intervention
No special intervention : Ultrasound data will be collected

Outcome Measures

Primary Outcome Measures

  1. Characteristics of pulmonary ultrasound for Covid-19 patients [Day one]

    description of ultrasound abnormalities for Covid-19 patients

Secondary Outcome Measures

  1. Characteristics of pulmonary ultrasound for Covid-19 patients [Day 3]

    description of ultrasound abnormalities for Covid-19 patients

  2. Characteristics of pulmonary ultrasound for Covid-19 patients [Day 14]

    description of ultrasound abnormalities for Covid-19 patients

  3. Charateristics of pulmonary CT-scan for Covid-19 patients [Day 1]

    description of CT-scan abnormalities for Covid-19 patients

  4. Charateristics of pulmonary CT-scan for Covid-19 patients [Day 3]

    description of CT-scan abnormalities for Covid-19 patients

  5. Charateristics of pulmonary CT-scan for Covid-19 patients [Day 14]

    description of CT-scan abnormalities for Covid-19 patients

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 105 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Patients admitted to hospital with proven COVID-19 infection with respiratory signs warranting a chest CT scan
Exclusion Criteria:
  • Patient not agreeing to have his or her data collected for the study

  • Unconscious patient

Contacts and Locations

Locations

Site City State Country Postal Code
1 CHU Amiens Amiens France 80054
2 CH de la Côte Basque Bayonne France 64109
3 CHU Ambroise Paré Boulogne-Billancourt France 92104
4 CHU Caen Caen France 14033
5 CHG de Chambery Chambéry France 73000
6 Centre Hospitalier Intercommunal de Créteil Créteil France 94000
7 CHU de Limoges Limoges France 87000
8 APHM - Hopital Nord Marseille France 13015
9 CHU de Nancy Nancy France 54035
10 CHU Nîmes Nîmes France 30029
11 CHR Orléans Orléans France 45100
12 CHU Cochin Paris France 75679
13 CHU Poitiers Poitiers France 86021
14 CHU Rouen Rouen France 76038
15 CH Saint-Quentin Saint-Quentin France 02321
16 CHU Larrey - Toulouse Toulouse France 31059
17 CHU de Tours Tours France 37000

Sponsors and Collaborators

  • Centre Hospitalier Intercommunal Creteil

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Centre Hospitalier Intercommunal Creteil
ClinicalTrials.gov Identifier:
NCT04341766
Other Study ID Numbers:
  • COVID-ECHO
First Posted:
Apr 10, 2020
Last Update Posted:
Jul 17, 2020
Last Verified:
Jul 1, 2020
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jul 17, 2020