PRA-MMP: Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure

Sponsor

University of Monastir (Other)

Overall Status

Completed

CT.gov ID

NCT02170961

Collaborator

(none)

300

Enrollment

Location

Actual Duration (Months)

6.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

this study aim to investigate the:

association of RAAS polymorphisms and AHF
association of MMP 3 and 12 polymorphisms and AHF

Condition or Disease	Intervention/Treatment	Phase
Acute Heart Failure

Detailed Description

Heart failure can be defined as a complex clinical syndrome that results from any structural or functional disorder of the heart, with impairment of ability to fill the ventricles or eject blood. The main event of the IC is dyspnea and fatigue, which limit exercise tolerance and induces water retention.

The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known.

To date, few published studies have examined the association between the polymorphism AGT M235T * and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.

Study Design

Study Type:

Observational

Actual Enrollment :

300 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Study of Polymorphisms of Renin Angiotensin Aldosteron Systemv(RAAS) and Matrice Metallo Protesase (MMPs) in Acute Heart Failure (AHF)

Actual Study Start Date :

Feb 1, 2013

Actual Primary Completion Date :

Dec 1, 2015

Actual Study Completion Date :

Dec 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
acute heart failure (AHF) patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data.
Non acute heart failure (NAHF) patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data.

Outcome Measures

Primary Outcome Measures

mortality RAAS [one year]
the association between RAAS genes polymorphisms and mortality at one year average

Secondary Outcome Measures

association between RAAS polymorphism and AHF [at admission (an average of 1 day)]
the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the RAAS genes polymorphism is studied at patient admission for acute dyspnea.
association between MMP polymorphism and AHF [at admission (average of 1 day)]
the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the MMP genes polymorphism is studied at patient admission for acute dyspnea.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

aged more than 18 year old.
acute non traumatic dyspnea .

Exclusion Criteria:

ECG diagnostic for acute myocardial infarction or ischemic chest pain within the prior 24 hours
a history of a heart transplant, pericardial effusion, chest wall deformity suspected of causing dyspnea
coma, shock,MV,vasopressor drugs
arrhythmia serious and sustained,
pace maker
severe mitral valve disease,