PETU: Positron Emission Tomography of Infection and Vasculitis
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to:
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investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia.
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study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp.
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find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis.
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study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator.
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investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Staphylococcus aureus bacteremia PET/CT in patients with Staphylococcus aureus bacteremia |
Radiation: PET/CT
positron emission tomography/computed tomography
|
| Salmonella spp. bacteremia PET/CT in patients with Salmonella spp. bacteremia |
Radiation: PET/CT
positron emission tomography/computed tomography
|
| Endocarditis PET/CT in patients with infective endocarditis |
Radiation: PET/CT
positron emission tomography/computed tomography
|
| Pacemaker infection PET/CT in patients with pacemaker infection |
Radiation: PET/CT
positron emission tomography/computed tomography
|
| Vasculitis PET/CT in patients with vasculitis |
Radiation: PET/CT
positron emission tomography/computed tomography
|
Outcome Measures
Primary Outcome Measures
- Detection of infection or vasculitis in PET images [within 1 week after starting the treatment]
Secondary Outcome Measures
- Standardized uptake value of PET imaging agent at the site of infection or vasculitis [within 1 week after starting the treatment]
Eligibility Criteria
Criteria
Inclusion Criteria:
Adults with
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Staphylococcus aureus bacteremia or
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Salmonella spp. bacteremia or
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infective endocarditis or
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infection of pacemaker or implantable cardioverter defibrillator or
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vasculitis
Exclusion Criteria:
- underage, pregnant, breastfeeding, handicapped or prisoner
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Turku University Hospital | Turku | Finland | FI-20521 |
Sponsors and Collaborators
- Turku University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 14824