Post-fracture Medication and Mortality
Study Details
Study Description
Brief Summary
Osteoporotic fracture is a common public-health problem in the whole world. Although postfracture usage of anti-osteoporosis medications, may reduce mortality, recent results have been inconsistent. The investigators aim to examine associations between osteoporosis medication and mortality in older adults and any type of fracture patients. The investigators also aim to discuss the pleiotropic effects of different types of anti-osteoporosis medications.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Osteoporotic fracture has become a serious health and economic burden as life expectancy increases. In a WHO report, the burden of osteoporotic fractures in 2002 was 2.8 million disability-adjusted life years, which is more than that for hypertension and slightly less than that for diabetes mellitus or chronic obstructive pulmonary diseases. Many patients who have had a diagnosed fracture have never been diagnosed with osteoporosis, therefore, closing the gap in osteoporosis treatment is important. This situation is primarily due to the fact that osteoporosis symptoms are often not recognized until a fracture occurs. Osteoporotic fractures, especially those of the hip and vertebral, are associated with an increased risk of death. Early detection of high risk for osteoporotic fractures is important; however, post-fracture management, especially interventions intended to lower mortality, is an emerging public health issue in rapidly aging societies. The burden of osteoporotic fracture is higher than that of hypertension, however, osteoporosis is always given less attention than other chronic diseases by health professionals and the general population.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Used osteoporosis medication Patients who had used osteoporosis medication after osteoporotic fractures. |
Drug: Anti-osteoporosis medications
Medication exposure was defined as the usage of osteoporosis medications approved by the Taiwan Food and Drug Administration (TFDA), including alendronate, risedronate, ibandronate, zoledronic acid, denosumab, raloxifene, bazedoxifene, calcitonin, and teriparatide, but excluded patients using the osteoporosis medication for cancer-related treatments (such as high dosing frequency of zoledronic acid or denosumab).
Other Names:
|
| Did not use osteoporosis medication Patients who didn't use osteoporosis medication after osteoporotic fractures. |
Drug: Anti-osteoporosis medications
Medication exposure was defined as the usage of osteoporosis medications approved by the Taiwan Food and Drug Administration (TFDA), including alendronate, risedronate, ibandronate, zoledronic acid, denosumab, raloxifene, bazedoxifene, calcitonin, and teriparatide, but excluded patients using the osteoporosis medication for cancer-related treatments (such as high dosing frequency of zoledronic acid or denosumab).
Other Names:
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Outcome Measures
Primary Outcome Measures
- Number of deaths with and without anti-osteoporotic therapy after hip fracture surgery [12 years]
This is the number of participants who died during the time of observation
- Number of deaths with or without anti-osteoporosis therapy after hip or vertebral fracture surgery among older adults [12 years]
This is the number of participants who died during the time of observation
- Number of deaths with and without bisphosphonates after hip or spine fracture surgery [12 years]
This is the number of participants who died during the time of observation
- Number of deaths with different types of anti-osteoporosis treatments after post-fracture [12 years]
This is the number of participants who died during the time of observation
- Number of deaths in five leading causes of death with and without anti-osteoporosis treatment after post-fracture [12 years]
This is the number of participants who died during the time of observation
Eligibility Criteria
Criteria
Inclusion Criteria:
- Newly diagnosed osteoporosis and hip fracture are defined as a claim record from the NHIRD between 2009 and 2017.
Exclusion Criteria:
- Patients with a diagnosis of osteoporosis or osteoporotic fractures in 2008 or before were excluded.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Family Medicine, National Cheng Kung Univ Hosp | Tainan | Taiwan |
Sponsors and Collaborators
- National Cheng-Kung University Hospital
Investigators
- Study Director: Chih-Hsing Wu, MD, National Cheng Kung University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Osteoporosis and Mortality