POCD: Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
Study Details
Study Description
Brief Summary
Post-operative cognitive dysfunction (POCD) is a common concern for aging patients undergoing elective orthopedic surgery and significantly effects health outcomes. This study aims to evaluate the incidence of and risk factors associated with post-operative cognitive dysfunction in aging patients without prior history for mild cognitive impairment or dementia.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Patients having surgery Older adults undergoing elective orthopedic surgery. |
Procedure: Elective Orthopedic Surgery
Patients having knee (unilateral primary osteoarthritis or bilateral primary osteoarthritis) surgery, hip (unilateral primary osteoarthritis or bilateral primary osteoarthritis) or shoulder (primary osteoarthritis) elective surgery.
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Outcome Measures
Primary Outcome Measures
- Presence of post operative cognitive dysfunction (POCD) [3 months]
Defined as a 1.5 standard deviation decline on any one of the cognitive test performed from baseline to three-months post surgery. Score range: 0-100. A higher score indicates more cases of incident of POCD.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age ≥50 and ≤90
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Any patient undergoing elective orthopedic surgery for hip, knee, or shoulder replacement (as defined by diagnostic codes: M16.0, M16.12, M16.11, M17.0, M17.12, M17.11, M19.011, M19.012)
Exclusion Criteria:
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History of cognitive impairment of dementia
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Montreal cognitive assessment (MoCA) <26
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History of Parkinson's disease, progressive supranuclear palsy, corticobasal degeneration, normal pressure hydrocephalus, Huntington's disease, stroke, seizure disorder, brain tumor, or brain surgery
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History of surgery requiring anesthesia within the past 3 months
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | HealthPartners Neuroscience Center | Saint Paul | Minnesota | United States | 55130 |
Sponsors and Collaborators
- HealthPartners Institute
Investigators
- Principal Investigator: Michael H Rosenbloom, MD, HealthPartners Neurology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- A19-224