Post-operative Functional Disability in Unrecognized Cognitive Impairment (POF) Study
Study Details
Study Description
Brief Summary
This is a prospective multicenter cohort study, which will determine the prevalence of unrecognized cognitive impairment (CI) using the Modified Telephone Interview for Cognitive Status (TICS- M), Eight-items interview to Differentiate Aging and Dementia (AD8), Telephone Montreal Cognitive Assessment (T-MoCA), and a single cognitive question from the Centers for Disease Control and Prevention (CDC). We would determine the correlation between CI and measures of postoperative delirium (POD), sleep disturbances, functional ability, and instrumental activities of daily living (IADL) in geriatric surgical patients. This study will target geriatric patients from the pre-operative clinics at Toronto Western Hospital, Toronto General Hospital, and Mount Sinai Hospital (MSH), Toronto. Research staff will identify eligible patients who are scheduled for elective non-cardiac surgery. Written informed consent to participate in the study will be obtained from all patients.
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Detailed Description
The primary aim of this study is to determine the prevalence of unrecognized cognitive impairment (CI) pre-operatively in older surgical adults using virtual or telephone cognitive instruments and its correlation to measures of POD, sleep disturbances, functional ability, and IADL.
In a preoperative assessment 1-30 days prior to their scheduled surgery, patients will be asked via telephone to complete TICS-M and T-MoCA and an online questionnaire, including the AD8, a single cognitive question, World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), Instrumental Activity of Daily Living (IADL), EuroQol 5 Dimension (EQ-5D-5L), Geriatric Depression Scale (GDS), 5-item FRAIL questionnaire, (FRAIL), visual analog pain scale (VAS pain), Single-item Sleep Quality Scale (SQS), Pittsburgh Sleep Quality Index (PSQI), and STOP. These questionnaires will be repeated at follow-up visits at 30-, 90-, and 180-days post-surgery. At the hospital on post-operatively days 1-3, the Confusion Assessment Method (CAM), visual analog sleep quality scale (VAS sleep quality), and VAS pain will be administered during the in-person visit. Chart review of delirium will also be conducted during patients' stay at the hospital.
Study Design
Outcome Measures
Primary Outcome Measures
- Cognitive Impairment via virtual assessment [30- days post-surgery]
Administration of cognitive status questionnaire
- Cognitive Impairment via virtual assessment [90-days post-surgery]
Administration of cognitive status questionnaire
- Cognitive Impairment via virtual assessment [180-days post-surgery]
Administration of cognitive status questionnaire
Eligibility Criteria
Criteria
Major Inclusion Criteria:
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patients ≥ 65 years old;
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patients scheduled for elective non-cardiac surgery
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and who are able to be contacted by telephone for follow up.
Major Exclusion Criteria:
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patients with previous dementia diagnosis,
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patients scheduled for outpatient surgery,
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Toronto General Hospital | Toronto | Ontario | Canada | M5G 2C4 |
| 2 | 399 Bathurst St., Toronto Western Hospital, Dept. of Anesthesia | Toronto | Ontario | Canada | M5T2S8 |
| 3 | Mount Sinai Hospital | Toronto | Ontario | Canada |
Sponsors and Collaborators
- Dr. Frances Chung
Investigators
- Principal Investigator: Frances Chung, MBBS MD FRCPC, University Health Network, Toronto
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20-6186