Intraoperative TAP Block After Repeat Cesarean
Study Details
Study Description
Brief Summary
The aim of this study is to perform a randomized trial to investigate if intraoperative surgeon administered TAP block reduces pain and use of oral and parenteral pain medications after repeat cesarean delivery. The investigators aim to compare surgeon administered TAP block with liposomal bupivacaine compared to standard treatment (i.e. no TAP block) with regard to the primary outcome of post-operative narcotic use.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Transversus abdominis plane (TAP) block is a well-described technique to provide a field block for analgesia. It has been shown to be effective in postoperative analgesia after cesarean delivery. TAP blocks are commonly performed post-operatively by anesthesiologists using liposomal bupivacaine with ultrasound guidance. Liposomal bupivacaine is an FDA approved medication for post-surgical analgesia and available at UMass-Memorial Medical Center. Liposomal bupivacaine provides sustained release of medication for up to 120 hours. A recent multicenter randomized controlled trial demonstrated the efficacy of anesthesiologist administered TAP blocks using liposomal bupivacaine after cesarean delivery. Infiltration of the skin and fascia with liposomal bupivacaine after cesarean did not have an effect and this can be explained by the path that the pain fibers take through the TAP which makes them amenable to a TAP block while a superficial infiltration is ineffective.The aim of this study is to perform a randomized trial to investigate if intraoperative surgeon administered TAP block reduces pain and use of oral and parenteral pain medications after repeat cesarean delivery. The investigators aim to compare surgeon administered TAP block with liposomal bupivacaine compared to standard treatment (i.e. no TAP block) with regard to the primary outcome of post-operative narcotic use.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: TAP Block Group Participants will receive a surgeon administered TAP block consisting of liposomal bupivacaine during their repeat cesarean delivery. |
Procedure: TAP Block Group
Participants will receive a surgeon administered TAP block.
|
| No Intervention: Standard of Care Postoperative Pain Control Participants will not receive a surgeon administered TAP block consisting of liposomal bupivacaine during their repeat cesarean delivery and will receive the routine standard of care for post-operative pain control. |
Outcome Measures
Primary Outcome Measures
- Daily Narcotic Use in Morphine Equivalents [From time of surgery through postpartum day 4]
Daily Narcotic Use in Morphine Equivalents
Secondary Outcome Measures
- Time to first administered narcotic (oral or parental) [From time of surgery through postpartum day 4]
Time to first administered narcotic (oral or parental) post cesarean delivery
- Daily Average Pain Score [From time of surgery through postpartum day 4]
Daily Average Pain Score based on ten point pain scale (minimum 0, maximum 10) with higher numbers indicating worse pain
- Daily Maximum Pain Score [From time of surgery through postpartum day 4]
Daily Average Pain Score based on ten point pain scale (minimum 0, maximum 10) with higher numbers indicating worse pain
- Time to First Ambulation [From time of surgery through postpartum day 4]
Time to First Ambulation post cesarean delivery
- Time to First Solid Food [From time of surgery through postpartum day 4]
Time to First Solid Food
Eligibility Criteria
Criteria
Inclusion Criteria:
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Pregnant women presenting for elective repeat cesarean delivery at 37-42 weeks gestational age.
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Pregnancy and delivery care obtained at UMass Memorial Medical Center
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Patients able to provide written informed consent
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English, Spanish, or Portuguese-speaking patients
Exclusion Criteria:
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Participants who are under the age of 18 years
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Active labor.
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Baseline pain score > 6.
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Unable to provide informed consent.
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Prisoners will be excluded from this research.
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Narcotic use in the 2 weeks prior to delivery.
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Active substance abuse.
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Inability to take narcotic analgesia.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Massachusetts, Worcester
Investigators
- Principal Investigator: Gianna Wilkie, MD, University of Massachusetts Chan Medical School
Study Documents (Full-Text)
None provided.More Information
Publications
- Abdallah FW, Halpern SH, Margarido CB. Transversus abdominis plane block for postoperative analgesia after Caesarean delivery performed under spinal anaesthesia? A systematic review and meta-analysis. Br J Anaesth. 2012 Nov;109(5):679-87. doi: 10.1093/bja/aes279. Epub 2012 Aug 19. Review.
- Kupiec A, Zwierzchowski J, Kowal-Janicka J, Goździk W, Fuchs T, Pomorski M, Zimmer M, Kübler A. The analgesic efficiency of transversus abdominis plane (TAP) block after caesarean delivery. Ginekol Pol. 2018;89(8):421-424. doi: 10.5603/GP.a2018.0072.
- Kwikiriza A, Kiwanuka JK, Firth PG, Hoeft MA, Modest VE, Ttendo SS. The analgesic effects of intrathecal morphine in comparison with ultrasound-guided transversus abdominis plane block after caesarean section: a randomised controlled trial at a Ugandan regional referral hospital. Anaesthesia. 2019 Feb;74(2):167-173. doi: 10.1111/anae.14467. Epub 2018 Nov 1.
- Mishriky BM, George RB, Habib AS. Transversus abdominis plane block for analgesia after Cesarean delivery: a systematic review and meta-analysis. Can J Anaesth. 2012 Aug;59(8):766-78. doi: 10.1007/s12630-012-9729-1. Epub 2012 May 24. Review.
- Tsai HC, Yoshida T, Chuang TY, Yang SF, Chang CC, Yao HY, Tai YT, Lin JA, Chen KY. Transversus Abdominis Plane Block: An Updated Review of Anatomy and Techniques. Biomed Res Int. 2017;2017:8284363. doi: 10.1155/2017/8284363. Epub 2017 Oct 31. Review.
- Wilson RD, Caughey AB, Wood SL, Macones GA, Wrench IJ, Huang J, Norman M, Pettersson K, Fawcett WJ, Shalabi MM, Metcalfe A, Gramlich L, Nelson G. Guidelines for Antenatal and Preoperative care in Cesarean Delivery: Enhanced Recovery After Surgery Society Recommendations (Part 1). Am J Obstet Gynecol. 2018 Dec;219(6):523.e1-523.e15. doi: 10.1016/j.ajog.2018.09.015. Epub 2018 Sep 18.
- STUDY00000407