Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)
Study Details
Study Description
Brief Summary
If pulmonary hypertension is suspected, a right heart catheterization is usually performed to confirm or rule out the diagnosis. As part of this examination, blood samples are taken from various locations as standard and blood gas analyses are performed. One of the most important measurements during the right heart catheterization is the measurement of the pulmonary arterial occlusion pressure by the so-called wedge maneuver. To measure this value, the catheter with inflated balloon must be advanced into the pulmonary vessels until the "wedge" position is reached, i.e. the balloon completely occludes a branch of the pulmonary artery. In this study, the investigators want to characterize patients with pulmonary hypertension of different causes in more detail. To do that, two blood samples (totaling approximately 4 mL of blood, one sample directly after occlusion and the other one two minutes later) will be drawn during the right heart catheterization from the above-mentioned "wedge" position", behind the inflated balloon, and blood gas analyses will be performed on these samples. In addition, various clinical parameters (comorbidities, etc.) will be recorded by means of clinical questionnaires. Follow-up data will be analyzed and correlations with the aforementioned blood gas analyses will be examined. The results of the study will be used to more precisely characterize the still vague concept of secondary pulmonary hypertension. This could help to develop new therapeutic strategies in some subgroups in the future.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No pulmonary Hypertension
|
Diagnostic Test: Blood gas analysis
Two blood samples will be drawn from the "wedge" position", behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.
|
| pulmonary Hypertension Group 1
|
Diagnostic Test: Blood gas analysis
Two blood samples will be drawn from the "wedge" position", behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.
|
| pulmonary Hypertension Group 2
|
Diagnostic Test: Blood gas analysis
Two blood samples will be drawn from the "wedge" position", behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.
|
| pulmonary Hypertension Group 3
|
Diagnostic Test: Blood gas analysis
Two blood samples will be drawn from the "wedge" position", behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.
|
| pulmonary Hypertension Group 4
|
Diagnostic Test: Blood gas analysis
Two blood samples will be drawn from the "wedge" position", behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.
|
| pulmonary Hypertension Group 5
|
Diagnostic Test: Blood gas analysis
Two blood samples will be drawn from the "wedge" position", behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.
|
Outcome Measures
Primary Outcome Measures
- Risk group after 3-6 months [3-6 months]
Standardized clinical outcome parameters after 3-6 months
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients who have a clearly defined indication for Right heart catheterization.
-
Age > 18 years
-
Informed consent for participation in the study will sign
Exclusion Criteria:
-
Individuals who are not fully capable of giving consent and understanding the nature, significance, and scope of the study
-
Pregnancy and lactation
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospital RWTH Aachen | Aachen | Germany | 52062 |
Sponsors and Collaborators
- Ayham Daher
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 21-063