Posterior Circulation ASTRAL Prognostic Score

Sponsor

University of Thessaly (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT05906420

Collaborator

University of Lausanne (Other)

2,000

Enrollment

Locations

248

Anticipated Duration (Months)

1000

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event <3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Condition or Disease	Intervention/Treatment	Phase
Stroke Ischemic Stroke Acute Posterior Circulation Brain Infarction	Diagnostic Test: ASTRAL prognostic score

Study Design

Study Type:

Observational

Anticipated Enrollment :

2000 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation

Actual Study Start Date :

Jan 1, 2003

Actual Primary Completion Date :

Dec 31, 2021

Anticipated Study Completion Date :

Aug 31, 2023

Arms and Interventions

Arm	Intervention/Treatment
ASTRAL	Diagnostic Test: ASTRAL prognostic score ASTRAL prognostic score

Arm

Intervention/Treatment

ASTRAL

Diagnostic Test: ASTRAL prognostic score

ASTRAL prognostic score

Outcome Measures

Primary Outcome Measures

3 months modified Ranking scale [January 2003-December 2021]
evaluation of 3 months neurological disability

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Isolated posterior circulation strokes based on clinical or/and imaging evidence.
Arriving within 24h at hospital since last proof of good health.

Exclusion Criteria:

no available data for 3 months modified Rankin Score
modified Rankin Score≥3 prior the event

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Medical School, University of Thessaly, Larissa University Hospital	Larissa	Thessaly	Greece	41110
2	Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne	Lausanne	Vaud Canton	Switzerland	1011

Sponsors and Collaborators

University of Thessaly
University of Lausanne

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

George Ntaios, Associate professor of Internal Medicine George Ntaios, University of Thessaly

ClinicalTrials.gov Identifier:

NCT05906420

Other Study ID Numbers:

pc-ASTRAL

First Posted:

Jun 15, 2023

Last Update Posted:

Jun 15, 2023

Last Verified:

Jun 1, 2023

Additional relevant MeSH terms:

Study Results

No Results Posted as of Jun 15, 2023