Comparison of Tab.Labetalol and Tab.Nifedipine for Management of Postpartum Hypertension

Sponsor

Dow University of Health Sciences (Other)

Overall Status

Unknown status

CT.gov ID

NCT02426177

Collaborator

(none)

Enrollment

Arms

19.1

Duration (Months)

Study Details

Study Description

Brief Summary

To compare effectiveness of oral labetalol and oral nifedipine for management of postpartum hypertension.

Condition or Disease	Intervention/Treatment	Phase
Postnatal Hypertension	Drug: Labetalol Drug: Nifedipine	Phase 3

Detailed Description

A comparison of oral labetalol and oral nifedipine for management of postpartum hypertension. Which drug is more effective in lowering blood pressures in patient with postpartum hypertension.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

98 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Treatment

Official Title:

Comparison of Oral Labetalol and Oral Nifedipine for Postpartum Hypertension Management

Study Start Date :

May 1, 2015

Anticipated Primary Completion Date :

May 1, 2016

Anticipated Study Completion Date :

Dec 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: group A tab.labetalol is given to the patient with postpartum hypertension in dose of 100 mg 6 hourly increased to maximum 600 mg in 24 hours	Drug: Labetalol anti-hypertensive agents
Active Comparator: group B tab.nifedipine is given to the patient with postpartum hypertension in the dose of 10 mg twice a day to maximum dose of 60 mg per 24 hours	Drug: Nifedipine calcium channel blocker ,for lowering blood pressure

Arm

Intervention/Treatment

Active Comparator: group A

tab.labetalol is given to the patient with postpartum hypertension in dose of 100 mg 6 hourly increased to maximum 600 mg in 24 hours

Drug: Labetalol

anti-hypertensive agents

Active Comparator: group B

tab.nifedipine is given to the patient with postpartum hypertension in the dose of 10 mg twice a day to maximum dose of 60 mg per 24 hours

Drug: Nifedipine

calcium channel blocker ,for lowering blood pressure

Outcome Measures

Primary Outcome Measures

Blood Pressure less than 140/90 mm of hg [24 hours]
less than 140/90 mm of hg

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 48 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

all women with postpartum hypertension as a continuation of pregnancy induced hypertension,eclampsia, pre-eclampsia or new onset de-novo postpartum hypertension,of any parity.
age group between 18-48.
after informed consent.

Exclusion Criteria:

all women with chronic hypertension, uncontrolled and un treated medical disorders will be excluded.
conditions in which drugs labetalol and nifedipine is contraindicated.