Study of Postprandial Incretin Response in Women With Gestational Diabetes

• Sponsor: University Hospital, Gentofte, Copenhagen (Other)
• Overall Status: Completed
• CT.gov ID: NCT01274052
• Collaborator: The Danish Diabetes Association (Other), Aase and Ejnar Danielsens Foundation (Other), The Novo Nordic Foundation (Other)
• Enrollment: 19
• Location: 1
• Duration (Months): 16
• Patients Per Site Per Month: 1.2

Study Details

Study Description

Brief Summary

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Condition or Disease	Intervention/Treatment	Phase
Gestational Diabetes Mellitus	Other: Meal test

Detailed Description

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Study Design

• Study Type: Observational
• Actual Enrollment: 19 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Reduced Postprandial GLP-1 Response in Gestational Diabetes Mellitus: a Fully Reversible Phenomenon
• Study Start Date: Mar 1, 2007
• Actual Primary Completion Date: Jul 1, 2008
• Actual Study Completion Date: Jul 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
Gestational Diabetes Mellitus Women with Gestational Diabetes Mellitus	Other: Meal test; Liquid meal test
Normal Glucose Tolerance Women with Normal Glucose Tolerance	Other: Meal test; Liquid meal test

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

• Ages Eligible for Study: N/A and Older
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Normal haemoblobin

• Willingness to participate

Exclusion Criteria:

• First degree relative with diabetes

• Diabetes before pregnancy

• Positive islet cell- and GAD-65 autoantibodies

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Internal Medicine, Glostrup Hospital	Glostrup		Denmark	2600

Sponsors and Collaborators

• University Hospital, Gentofte, Copenhagen
• The Danish Diabetes Association
• Aase and Ejnar Danielsens Foundation
• The Novo Nordic Foundation

Investigators

• Principal Investigator: Filip K Knop, MD PhD, Diabetes Research Division, Gentofte Hopsital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01274052
• Other Study ID Numbers: KA-060015
• First Posted: Jan 11, 2011
• Last Update Posted: Jan 11, 2011
• Last Verified: Jan 1, 2011

• Keywords provided by , ,: Gestational diabetes mellitus; Meal test; Incretin hormones; Glucagon-like peptide-1 (GLP-1); Glucose-dependent insulinotropic polypeptide; Insulin; C-peptide; Glucagon
• Additional relevant MeSH terms: Diabetes, Gestational; Diabetes Mellitus

Study Results

No Results Posted as of Jan 11, 2011