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Postprandial VLDL-TG Metabolism

Sponsor
University of Aarhus (Other)
Overall Status
Completed
CT.gov ID
NCT01961024
Collaborator
(none)
21
Enrollment
1
Location
19
Duration (Months)
1.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    21 participants
    Observational Model:
    Cohort
    Time Perspective:
    Cross-Sectional
    Official Title:
    Postprandial VLDL-TG Metabolism
    Study Start Date :
    Jan 1, 2014
    Actual Primary Completion Date :
    Aug 1, 2015
    Actual Study Completion Date :
    Aug 1, 2015

    Arms and Interventions

    Arm Intervention/Treatment
    Type 2 diabetic men
    Age- and weight-matched controls

    Outcome Measures

    Primary Outcome Measures

    1. VLDL-TG storage in adipose tissue [3 hours]

    Secondary Outcome Measures

    1. 18F-THA fractional storage [6 Hours]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    30 Years to 70 Years
    Sexes Eligible for Study:
    Male
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Written consent
    Exclusion Criteria:

    • Known diseases

    • Alcohol abuse

    • Smoker

    • Regular use of medicine

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Department of Endocrinology MEA, Aarhus Hospital Aarhus C Please Select Denmark 8000

    Sponsors and Collaborators

    • University of Aarhus

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Esben Søndergaard, Post Doc, MD, PhD, University of Aarhus
    ClinicalTrials.gov Identifier:
    NCT01961024
    Other Study ID Numbers:
    • ES-0006
    First Posted:
    Oct 11, 2013
    Last Update Posted:
    May 3, 2017
    Last Verified:
    May 1, 2017
    Keywords provided by Esben Søndergaard, Post Doc, MD, PhD, University of Aarhus
    VLDL-TG kinetics
    Postprandial state
    Obesity

    Study Results

    No Results Posted as of May 3, 2017