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Preconditioning Volatile Anesthesia in Liver Surgery

Sponsor
University of Zurich (Other)
Overall Status
Completed
CT.gov ID
NCT01021228
Collaborator
(none)
257
Enrollment
1
Location
14
Duration (Months)
18.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to compare the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Comparing the impact and outcome of continuous volatile anesthesia to continuous intravenous anesthesia and to preconditioning volatile anesthesia in liver surgery.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    257 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Preconditioning is Indeed Protective
    Study Start Date :
    Aug 1, 2008
    Actual Primary Completion Date :
    Oct 1, 2009
    Actual Study Completion Date :
    Oct 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    group1

    continuous volatile anesthesia (sevoflurane) during the liver resection
    group2

    continuous intravenous anesthesia (propofol) during the liver resection
    group3

    preconditioning volatile anesthesia (sevoflurane) 30 minutes before ischemia (inflow occlusion)

    Outcome Measures

    Primary Outcome Measures

    1. peak ALT and AST levels representing the ischemia-reperfusion injury [post-operative]

    Secondary Outcome Measures

    1. length of hospital stay, length of ICU stay, blood loss and morbidity (post-operative complications) [post-operative]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 90 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • 18 years

    • benign and malign disease

    • any type of liver surgery

    • inflow occlusion during the liver surgery

    Exclusion Criteria:

    • < 18 years

    • participation on other interventional and treatment randomized controlled trials,

    • trauma of the liver

    • liver cirrhosis

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Universtiy Hospital of Zurich, Department of Visceral and Transplantation Surgery Zurich Switzerland 8091

    Sponsors and Collaborators

    • University of Zurich

    Investigators

    • Principal Investigator: Ksenija Slankamenac, med. pract, Departement of Visceral and Transplantation

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT01021228
    Other Study ID Numbers:
    • StV 18-2008
    First Posted:
    Nov 26, 2009
    Last Update Posted:
    Nov 26, 2009
    Last Verified:
    Nov 1, 2009
    Keywords provided by , ,
    Liver resection
    Continuous volatile anesthesia
    Continuous intravenous anesthesia
    Preconditioning volatile anesthesia
    Comparing three groups of anesthesia during the liver surgery according to their benefit on liver and outcome.

    Study Results

    No Results Posted as of Nov 26, 2009