Predicting Acute Kidney Injury After Coronary Artery Bypass Graft
Study Details
Study Description
Brief Summary
Acute kidney injury after cardiac surgery is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. There have been many studies reporting risk factor of acute kidney injury after cardiac surgery, but the influence of perioperative variables related to anesthesia and perioperative medication has not been evaluated fully. The investigators attempt to evaluate the influence of perioperative clinical variables including preoperative medication, preoperative albumin level, uric acid concentration, anesthesia technique, use of hydroxyethyl starch, blood glucose level, intraoperative medication, perioperative cardiac function (systolic and diastolic function) and hemodynamic variables during surgery on the incidence of acute kidney injury after coronary artery bypass graft.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Acute kidney injury (AKI) after cardiac surgery is a major complication after cardiac surgery and has been reported to be associated with adverse outcome. There have been many studies reporting risk factor of acute kidney injury after cardiac surgery, but the influence of perioperative variables related to anesthesia and perioperative medication has not been evaluated fully. The investigators attempt to evaluate the influence of preoperative medication, preoperative albumin level, uric acid concentration, NL ratio, anesthesia technique, use of hydroxyethyl starch, blood glucose level, intraoperative medication, perioperative cardiac function (systolic and diastolic) and hemodynamic variables during surgery on the incidence of acute kidney injury after coronary artery bypass graft. Preoperative and postoperative diastolic dysfunction may be associated with postoperative AKI. In addition, preoperative neutrophil-lymphocyte ratio (NLR) which has been reported to be a marked for systemic inflammation and was associated with prognosis in cardiac patients undergoing coronary artery bypass graft or percutaneous coronary intervention. This preoperative or immediate postoperative NLR might be able to predict AKI after coronary artery bypass surgery.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Coronary artery bypass surgery patients who underwent coronary artery bypass surgery between 2010 and 2012 in Samsung Medical Center |
Procedure: Coronary artery bypass surgery
coronary artery bypass surgery
|
Outcome Measures
Primary Outcome Measures
- Acute kidney injury diagnosis defined by KDIGO criteria [during 7 days after surgery]
Acute kidney injury diagnosis defined by KDIGO criteria (Stage 1, 2, 3) during seven days after surgery
Secondary Outcome Measures
- Acute kidney injury as defined by AKIN (acute kidney injury network) criteria [within 48 hours after surgery]
Acute kidney injury as defined by AKIN (acute kidney injury network) criteria
Eligibility Criteria
Criteria
Inclusion Criteria:
- patients who underwent coronary artery bypass surgery during between 2010 and 2012 in Samsung Medical Center
Exclusion Criteria:
-
lack of postoperative creatinine or urine output data
-
patients who expired within 24hours after surgery
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Samsung Medical Center | Seoul | Korea, Republic of | 135-710 |
Sponsors and Collaborators
- Samsung Medical Center
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2013-12-116