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The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

Sponsor
Beijing Chao Yang Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT02820090
Collaborator
(none)
300
Enrollment
35
Duration (Months)

Study Details

Study Description

Brief Summary

Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    300 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
    Study Start Date :
    May 1, 2014
    Anticipated Primary Completion Date :
    Apr 1, 2017
    Anticipated Study Completion Date :
    Apr 1, 2017

    Arms and Interventions

    Arm Intervention/Treatment
    Success with SBT

    The patient have a success in SBT.
    Success with mechanical ventilation

    Weaning from mechanical ventilation is successful
    failure with SBT

    The patient have a failure in SBT.
    failure with mechanical ventilation

    Weaning from mechanical ventilation is failed

    Outcome Measures

    Primary Outcome Measures

    1. The relationship between mechanical ventilation of ventilator and inflammatory response [January 2014 to December 2016]

      Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related.

    Secondary Outcome Measures

    1. The relationship between diaphragm movement function and weaning from mechanical ventilation [January 2016 to December 2017]

      To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation.

    2. the output of CO2 [January 2016 to December 2017]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    14 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure

    • mechanical ventilation time over than 48 hours

    • Glasgow score greater more than or equal to 13 points

    Exclusion Criteria:

    • Aged less than 14 years or more than 80 years old

    • patients with neuromuscular disease

    • pure heart failure pulmonary edema patients

    • patients with tracheotomy

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Beijing Chao Yang Hospital

    Investigators

    • Study Director: MA yingmin, professor, Beijing Chao Yang Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Yingmin Ma, Vice President of the Beijing Chao Yang Hospital, Beijing Chao Yang Hospital
    ClinicalTrials.gov Identifier:
    NCT02820090
    Other Study ID Numbers:
    • 15210511726
    First Posted:
    Jun 30, 2016
    Last Update Posted:
    Jun 30, 2016
    Last Verified:
    Jun 1, 2016
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Keywords provided by Yingmin Ma, Vice President of the Beijing Chao Yang Hospital, Beijing Chao Yang Hospital
    Inflammatory Factor
    Mechanical Ventilation
    Additional relevant MeSH terms:
    Systemic Inflammatory Response Syndrome

    Study Results

    No Results Posted as of Jun 30, 2016