Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU
Study Details
Study Description
Brief Summary
Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound.
The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index.
Patients will be divided into 2 groups:
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Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI).
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Group (B) patients with renal resistive index more than 0.7 (high RRI).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients with RRI between 0.6 and 0.7 Normal renal resistive index |
Diagnostic Test: Renal Doppler Ultrasound
Measurement of Renal resistive index
|
| Patients with RRI more than 0.7 High renal resistive index |
Diagnostic Test: Renal Doppler Ultrasound
Measurement of Renal resistive index
|
Outcome Measures
Primary Outcome Measures
- incidence of AKI [1 day at admission]
incidence of AKI related to Renal resistive index.
Secondary Outcome Measures
- APACHE III score [1 day at admission]
Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 299 worse)
- APACHE IV score [1 day at admission]
Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 286 worse)
- SOFA score [1 day at admission]
Sequential Organ Failure Assessment (SOFA) score. Score Range (0 better - 24 worse)
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature >38°C or <36°C, Heart rate >90/min, Respiratory rate
20/min or PaCO2 <32mmHg (4.3kPa) and White blood cell count >12000/mm3 or <4000/mm3 or >10% immature bands.) in addition to suspected or confirmed infection.
- Patients who have normal renal function on admission.
Exclusion Criteria:
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Currently recovering from an AKI at the time of inclusion and Renal impairment on admission.
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Patients with obstructive renal failure, renal artery stenosis were excluded from this study.
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Patients on chemotherapy and/or radiotherapy.
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Pregnancy.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ain Shams University Hospitals | Cairo | Egypt |
Sponsors and Collaborators
- Ain Shams University
Investigators
- Study Director: Mohamed Saleh Ahmed, MD, Lecturer of Anesthesia and Intensive Care
- Study Chair: Mohammed Saeed Abdelaziz, MD, Professor of Anesthesia and Intensive Care
- Study Director: Mona Refaat Hosney, MD, Assistant Professor of Anesthesia and Intensive Care
- Principal Investigator: Ahmed Abdelsattar Abuelmajd, MBBCH, Candidate of master degree in general intensive care
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- FMASU M S 299 / 2020