Predictive Value of Epicardial Adipose Tissue for Pulmonary Embolism and Death in Patients With Lung Cancer
Study Details
Study Description
Brief Summary
The occurrence and progression of lung cancer is related to visceral adipose tissue (VAT). Epicardial adipose tissue (EAT) is a kind of VAT, producing a variety of inflammatory cytokines and adipokines, participating in the formation of local inflammation, promoting the formation of pre-thrombotic state, and leading to the occurrence of thromboembolism. Patients with lung cancer have increased inflammatory response and are more prone to suffer thrombosis. However, in lung cancer patients, the clinical correlation between EAT and pulmonary embolism has not been reported. Objective: To analyze the risk factors of poor prognosis in lung cancer patients with PE, and to explore the predictive value of EAT in pulmonary embolism events and death in lung cancer patients. Methods: EAT volume and density, as well as anthropometric and blood biomarkers, were evaluated in a sample of lung cancer patients, half with pulmonary embolism and half without. The incidence of adverse prognosis and related factors were followed up by telephone.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| PE group The CTPA diagnosis suggest pulmonary embolism |
Diagnostic Test: CTPA (computed tomography pulmonary angiography)
The CTPA diagnosis suggest or did not suggest pulmonary embolism.
|
| control group The CTPA diagnosis did not suggest pulmonary embolism |
Diagnostic Test: CTPA (computed tomography pulmonary angiography)
The CTPA diagnosis suggest or did not suggest pulmonary embolism.
|
Outcome Measures
Primary Outcome Measures
- EAT volume [May, 20, 2023]
volume of epicardial adipose tissue (EAT), Cm3
- EAT density [May, 20, 2023]
density of epicardial adipose tissue (EAT) , Hounsfield Units (HU)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
The pathological diagnosis was lung cancer
-
Pulmonary artery was evaluated by CTA during hospitalization.
Exclusion Criteria:
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Patients with incomplete clinical data
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Patients with no follow-up data
-
Patients with a history of PE before diagnosis of lung cancer
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | First Affiliated Hospital of Xian Jiaotong University | Xi'an | Shaanxi | China | 710061 |
Sponsors and Collaborators
- First Affiliated Hospital Xi'an Jiaotong University
Investigators
- Study Director: Yang Yan, First Affiliated Hospital Xi'an Jiaotong University
- Principal Investigator: Haichen Wang, First Affiliated Hospital Xi'an Jiaotong University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- XJTU1AF2023LSK-269