Predictors of Cord Blood Immunoglobin E (IgE) Levels
Study Details
Study Description
Brief Summary
Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.
Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.
Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Prenatal factors Prenatal factors to predict cord blood IgE |
Outcome Measures
Primary Outcome Measures
- cord blood IgE [at birth]
Secondary Outcome Measures
- Cord blood cytokines or other mediators [at birth]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Mothers in pregnancy 18 years of age or older, AND
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Mothers able to speak Chinese.
Exclusion Criteria:
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Infant delivered at less than 36 weeks' gestation,
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Infant with Apgar score in 5 minutes after birth < 7,
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Infant with a major congenital anomaly, OR
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Infant admitted to an intensive care unit.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Min-Sheng General Hospital | Taoyuan | Taiwan |
Sponsors and Collaborators
- Min-Sheng General Hospital
Investigators
- Principal Investigator: Chien-Han Chen, MD, Min-Sheng General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2009008