RPOH: Effects of Recurrent PE on Women and Offspring
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| control pregnancy without preeclampsia |
Other: blood pressure,BMI, blood sample
Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.
|
| preeclampsia pregnancy complicated with preeclampsia at the first delivery or at the second delivery |
Other: blood pressure,BMI, blood sample
Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.
|
| recurrent preeclampsia pregnancy complicated with preeclampsia at two deliveries |
Other: blood pressure,BMI, blood sample
Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.
|
Outcome Measures
Primary Outcome Measures
- blood pressure and hypertension of women [1year after the second deliver]
blood pressure ≥140/90 mmHg
- blood pressure and hypertension of women [3 years after the second deliver]
blood pressure ≥140/90 mmHg
- blood pressure and hypertension of women [5 years after the second deliver]
blood pressure ≥140/90 mmHg
- blood pressure and hypertension of offspring [1 year old]
blood pressure≥140/90 mmHg
- blood pressure and hypertension of offspring [3 years old]
blood pressure≥140/90 mmHg
- blood pressure and hypertension of offspring [5 years old]
blood pressure≥140/90 mmHg
- level of glycosylated hemoglobin in blood [1 year after the second deliver]
women
- level of glycosylated hemoglobin in blood [3 years after the second deliver]
women
- level of glycosylated hemoglobin in blood [5 years after the second deliver]
women
- level of cholesterol, LDL, HDL, VLDL-C in blood [1 year after the second deliver]
women
- level of cholesterol, LDL, HDL, VLDL-C in blood [3 years after the second deliver]
women
- level of cholesterol, LDL, HDL, VLDL-C in blood [5 years after the second deliver]
women
- level of FT3,FT4, and hTSH in blood [1year after the second deliver]
women
- level of FT3,FT4, and hTSH in blood [3 years after the second deliver]
women
- level of FT3,FT4, and hTSH in blood [5 years after the second deliver]
women
- level of AST and ALT in blood [1year after the second deliver]
women
- level of AST and ALT in blood [3 years after the second deliver]
women
- level of AST and ALT in blood [5 years after the second deliver]
women
Secondary Outcome Measures
- BMI of offspring [1 year old]
weight(kg)/height(m)2
- BMI of offspring [3 years old]
weight(kg)/height(m)2
- BMI of offspring [5 years old]
weight(kg)/height(m)2
- level of insulin in blood [1year after the second deliver]
women
- level of insulin in blood [3 years after the second deliver]
women
- level of insulin in blood [5 years after the second deliver]
women
- level of fructosamine in blood [1year after the second deliver]
women
- level of fructosamine in blood [3 years after the second deliver]
women
- level of fructosamine in blood [5 years after the second deliver]
women
- level of AI37℃、AI4℃、PRA、ALD、AngII in blood [1 year after the second deliver]
women
- level of AI37℃、AI4℃、PRA、ALD、AngII in blood [3 years after the second deliver]
women
- level of AI37℃、AI4℃、PRA、ALD、AngII in blood [5 years after the second deliver]
women
Eligibility Criteria
Criteria
Inclusion Criteria:
- women with at least twice of delivery history
Exclusion Criteria:
- women with chronic hypertension
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou | China | 510150 |
Sponsors and Collaborators
- Dunjin Chen
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 81830045