Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Sponsor

Nantes University Hospital (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT06059313

Collaborator

(none)

120

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility.

The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

Condition or Disease	Intervention/Treatment	Phase
Behavioral Variant of Frontotemporal Disorder (bvFTD) Phenocopy Frontotemporal Dementia (phFTD) Frontal Variant of Alzheimer Disease Bipolar Disorder	Other: Submission of the NEO-PI-3 questionnaire Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)

Study Design

Study Type:

Observational

Anticipated Enrollment :

120 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Relationship Between Premorbid Personality Traits and Cognitive and Behavioral Disorders

Anticipated Study Start Date :

Oct 1, 2023

Anticipated Primary Completion Date :

Oct 1, 2026

Anticipated Study Completion Date :

Feb 1, 2027

Arms and Interventions

Arm	Intervention/Treatment
Behavioral variant of frontotemporal disorder (bvFTD) A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia	Other: Submission of the NEO-PI-3 questionnaire The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree). Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI) The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.
Phenocopy frontotemporal dementia (phFTD) A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities.	Other: Submission of the NEO-PI-3 questionnaire The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree). Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI) The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.
Frontal variant of Alzheimer disease A group of participants who fulfill Ossenkopele criteria (2022)	Other: Submission of the NEO-PI-3 questionnaire The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree). Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI) The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.
Bipolar disorder A group of participants who fulfill CIM 10 criteria	Other: Submission of the NEO-PI-3 questionnaire The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree). Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI) The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.

Outcome Measures

Primary Outcome Measures

Premorbid personality traits [Baseline]
Premorbid personality traits will be assessed by the NEO- NEO Personality Inventory-3 (NEO-PI-3). The NEO PI-3 measures the five major domains of personality: Neuroticism, Extraversion, Openness to experience, Conscientiousness and Agreeableness. Each domain is defined by 6 facets. NEOPI-3 includes 240 items and responses are made on a 5-point Likert -type scale ranging from strongly Disagree to strongly agree. The NEOPI 3 will be completed by a caregiver who has known the patient in the 10 years preceding the disease onset.

Secondary Outcome Measures

Interpersonal Reactivity Index (IRI) [Baseline]
IRI is a 28-item questionnaire measuring 4 aspects of empathy : perspective-taking, fantasy, empathic concern, personal distress. Each answer is rated from 1 (does not describe me well) to 5 (describes me very well).

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria :

Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria
Score for Mini-mental state examination ≥ 18
Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset.
Patient and caregiver consents (no opposition)