Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study
Study Details
Study Description
Brief Summary
Sore throat includes specific symptoms such as dysphagia, dysphonia, hoarseness, continuous throat pain, and pharyngeal dryness. Patients rated postoperative sore throat (POST) as the eighth most undesirable outcome in the postoperative period POST has a reported incidence of up to 62% following general anesthesia (GA). The incidence of POST is more common in GA with tracheal intubation than in GA with the supraglottic airway Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist and has been used as a gargle for reducing the incidence and severity of POST due to its anti-nociceptive and anti-inflammatory effects
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| (K) Ketamine group 40 patients will receive ketamine 50mg (1.0 ml with 4.0 ml of the saline) nebulization |
Drug: Ketamine
description
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| (S) Saline group 40 patients will receive saline nebulization (5ml). |
Other: saline nebulization
description
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Outcome Measures
Primary Outcome Measures
- the incidence and severity of POST [at immediate recovery (0 h), 2, 4, 6, 8, 12 and 24 h post-operatively.]
the study is to measure the incidence and severity of POST at immediate recovery (0 h), 2, 4, 6, 8, 12 and 24 h post-operatively. in adult patients undergoing surgery of a duration less than 2h.
Secondary Outcome Measures
- evaluation of side effects including nausea, vomiting, cough, and dry mouth in both groups. [at immediate recovery (0 h), 2, 4, 6, 8, 12 and 24 h post-operatively.]
evaluation of side effects including nausea, vomiting, cough, and dry mouth in both groups.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 16-60 years.
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Of both sex.
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American Society of Anesthesiologists Physical Status (ASA PS) I-II.
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Undergoing general anesthesia with endotracheal intubation with surgery duration less than two hours.
Exclusion Criteria:
- a- History of chronic obstructive History of sore throat or upper respiratory tract infection.
b- Intraoral and intrapharyngeal surgery. c- airway disease or Asthma. d- Mallampati grade more than II. e- Known allergic to study drug. f- More than one attempt is required for intubation. g- Hypertensive patients. h- Epileptic patients. i- cerebral palsy or any neurological disorders. j- Psychiatry patients. k- Cardiac patients. l- Perioperative use of anti-inflammatory drugs (Non-steroidal anti-inflammatory drug or steroids).
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Sohag University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Cairns A, Battleday FM, Velikova G, Brunelli A, Bell H, Favo J, Patella M, Lindner O, Pompili C. General patient satisfaction after elective and acute thoracic surgery is associated with postoperative complications. J Thorac Dis. 2020 May;12(5):2088-2095. doi: 10.21037/jtd-19-3345b.
- Hailu S, Shiferaw A, Regasa T, Getahun YA, Mossie A, Besha A. Incidence of Postoperative Sore Throat and Associated Factors Among Pediatric Patients Undergoing Surgery Under General Anesthesia at Hawassa University Comprehensive Specialized Hospital, a Prospective Cohort Study. Int J Gen Med. 2023 Feb 18;16:589-598. doi: 10.2147/IJGM.S397519. eCollection 2023. Erratum In: Int J Gen Med. 2023 Apr 06;16:1237-1238.
- Thomas D, Bejoy R, Zabrin N, Beevi S. Preoperative ketamine nebulization attenuates the incidence and severity of postoperative sore throat: A randomized controlled clinical trial. Saudi J Anaesth. 2018 Jul-Sep;12(3):440-445. doi: 10.4103/sja.SJA_47_18.
- soh-Med-23-07-20MS