Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer
Study Details
Study Description
Brief Summary
The aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes. The study will include 120 colorectal cancer patients who are scheduled for surgical treatment.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
A questionnaire form containing general information, dietary habits, and food consumption records will be applied by the researcher in the preoperative period to the patients who volunteered to participate in the study. Body composition will be taken by bioelectrical impedance analysis method, and waist circumference, hip circumference, mid upper arm circumference, and calf circumference will be measured with a non-stretchable tape measure. Hand grip strength will be taken with a digital hand dynamometer. The nutritional status of patients will be assessed using the criteria of the Nutritional Risk Screening 2002 (NRS-2002), the Global Leadership Initiative on Malnutrition (GLIM) and the Patient Generated Subjective Global Assessment (PG-SGA). For body composition analysis, computed tomography images, known as the gold standard, will be used in cancer patients. Computed tomography images of the patients will be obtained from hospital records at L3 lumbar vertebra level. The software program ImageJ developed by the US National Institute of Health will be used to calculate the visceral fat area (cm2), subcutaneous fat area (cm2), and skeletal muscle area (cm2) from the recorded images.
Preoperative biochemical parameters will be obtained from hospital records. The systemic inflammatory response will be determined by the Prognostic Nutritional Index, Neutrophil Lymphocyte Ratio, and Delta Neutrophil Index. The inflammatory load of the diet will be calculated using the Dietary Inflammatory Index. The quality of life of patients will be assessed using cancer-specific scales developed by the European Organisation for Research and Treatment of Cancer (EORTC) during the preoperative and postoperative periods. These scales are EORTC-QLQ-C30 for general quality of life and EORTC-QLQ-CR29 for colorectal cancer-specific quality of life.
Study Design
Outcome Measures
Primary Outcome Measures
- Postoperative complications [within 30 days after surgery]
Complications graded by Clavien-Dindo Complication Classification System
- Postoperative quality of life [within 45 days after surgery]
Quality of life will be evaluated by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30).All of the scales and single-item measures range in score from 0 to 100. A high scale score represents a higher response level.
- EORTC-QLQ-CR29 [within 45 days after surgery]
European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal Cancer 29 (EORTC-QLQ-CR29) is a supplementary questionnaire module to be employed in conjunction with the Quality of Life Questionnaire Core 30 (QLQ-C30). All of the scales and single-item measures range in score from 0 to 100. A high score for the functional scale and functional single-items represents a high level of functioning, whereas a high score for the symptom scales and symptom single-items represents a high level of symptomatology or problem.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Having been diagnosed with colorectal cancer and having surgical treatment planned
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Being 18 years of age or older
Exclusion Criteria:
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Having received chemotherapy or radiotherapy
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Currently undergoing corticosteroid or hormone treatment.
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Presence of distant metastases.
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Presence of any malignancy other than colorectal cancer.
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Presence of autoimmune disease.
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Presence of ongoing infectious disease.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hacettepe University | Ankara | Turkey | 06100 | |
| 2 | Ankara City Hospital Bilkent | Ankara | Turkey | 06800 |
Sponsors and Collaborators
- Hacettepe University
- Ankara City Hospital Bilkent
Investigators
- Principal Investigator: Tuba N Yildiz Kopuz, Hacettepe University
- Principal Investigator: Mehmet Fisunoglu, Hacettepe University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GO 21/499