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Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging

Sponsor
Tang-Du Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT03212027
Collaborator
(none)
60
Enrollment
9
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The aim of this study is to analyze aquaporins expression of thymic epithelial tumors and to compare them with apparent diffusion coefficient(ADC) from ultra-high b-values, and to test a possibility of use of ADCuh to identify the pathological type of tumor.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Magnetic resonance (MR) diffusion-weighted imaging (DWI) measures water diffusion in biological tissue. The quantification of diffusion is described by the apparent diffusion coefficient (ADC),which largely depends on the number and separation of barriers.Thus, ADC can provide information regarding tissue microstructure.

    According to the literature, ADC is also related to cell membrane permeability for water molecules.It is well known that cellular water transport depends on aquaporins (AQPs).In general,the expression of aquaporins might differ in several pathologic disorders. With reference to this fact,we hypothesize that AQPs expression may influence ADC in thymic epithelial tumors(TETs).Therefore,the aim of the present study is to analyze possible associations between ADC from ultra-high b-values and AQPs expression(ADCuh) in TETs and to use ADCuh to identify the pathological type of tumor.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    60 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Preoperative Prediction of the Pathological Classification of Thymic Epithelial Tumors by Apparent Diffusion Coefficient Using Ultra-high B-values
    Anticipated Study Start Date :
    Jul 31, 2017
    Anticipated Primary Completion Date :
    Jan 1, 2018
    Anticipated Study Completion Date :
    May 1, 2018

    Arms and Interventions

    Arm Intervention/Treatment
    Patients with low-risk thymomas

    low-risk thymomas include types A, AB, and B1 thymomas
    Patients with high-risk thymomas

    high-risk thymomas include types B2 and B3 thymomas
    Patients with thymic carcinomas

    thymic carcinomas also called types C thymomas

    Outcome Measures

    Primary Outcome Measures

    1. Different DWI parameters in thymic epithelial tumors [6 months]

    Secondary Outcome Measures

    1. To acquire aquaporins expression level of thymic epithelial tumors [6 months]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • no use of corticosteroid drugs;

    • no MRI contraindication;

    • no infection or fever;

    • tumor diameter is greater than 2cm.

    Exclusion Criteria:

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Tang-Du Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Tang-Du Hospital
    ClinicalTrials.gov Identifier:
    NCT03212027
    Other Study ID Numbers:
    • 2016SF-211
    First Posted:
    Jul 11, 2017
    Last Update Posted:
    Jul 18, 2017
    Last Verified:
    Jul 1, 2017
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Tang-Du Hospital
    apparent diffusion coefficient
    aquaporins
    Additional relevant MeSH terms:
    Neoplasms, Glandular and Epithelial
    Thymus Neoplasms

    Study Results

    No Results Posted as of Jul 18, 2017