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Preoperative Serum Albumin and Duration of Intraoperative Hypotension on Postoperative Acute Kidney Injury

Sponsor
Peking University First Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT03882658
Collaborator
(none)
37,610
Enrollment
1
Location
13.2
Actual Duration (Months)
2854.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Acute kidney injury is one of major adverse postoperative complications. research about postoperative acute kidney injury conclude that low preoperative albumin and intraoperative hypotension is associated to postoperative acute kidney injury. However, due to ethic issue and nonlinear realtionship between these factors and postoperative acute kidney injury, the exact threshold of these two risk factors were not be able to identified. The research tried to locate the exact threshold with implementation of penalized splines by generalized additive model.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    37610 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Preoperative Serum Albumin and Duration of Intraoperative Hypotension on Postoperative Acute Kidney Injury: a Retrospective Cohort Analysis
    Actual Study Start Date :
    Jan 10, 2018
    Actual Primary Completion Date :
    Jan 20, 2019
    Actual Study Completion Date :
    Feb 15, 2019

    Outcome Measures

    Primary Outcome Measures

    1. incidence and odds ratio of postoperative acute kidney injury [30 days postoperatively in hospital]

      incidence and odds ratio of postoperative acute kidney injury

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 100 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    adult non-cardiac, non-obsteric, non- kidney elective surgery patients

    Exclusion Criteria:

    patients aged <18 y emergency surgeries without arterial blood pressure cardiac surgeries obstetric surgeries kidney surgeries under local infiltration or MAC first SBP <100 mmHg

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 First hospital Peking University Beijing Beijing China 100034

    Sponsors and Collaborators

    • Peking University First Hospital

    Investigators

    • Principal Investigator: Yan Zhou, MD, PhD, Peking University First Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Yan Zhou, MD, Principal Investigator, Peking University First Hospital
    ClinicalTrials.gov Identifier:
    NCT03882658
    Other Study ID Numbers:
    • ALBHYTAKI
    First Posted:
    Mar 20, 2019
    Last Update Posted:
    May 7, 2019
    Last Verified:
    May 1, 2019
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Acute Kidney Injury
    Hypotension
    Wounds and Injuries

    Study Results

    No Results Posted as of May 7, 2019