The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Sponsor

Samsung Medical Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT00624039

Collaborator

(none)

Enrollment

Location

Arm

Duration (Months)

0.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility.

Condition or Disease	Intervention/Treatment	Phase
Presbyopia Cataract	Other: UBM with pilocarpine in presbyopia	N/A

Detailed Description

The functional changes in the ciliary body in presbyopia are not only important in a study of the mechanism for presbyopia but are also a key to various procedures or devices used to restore accommodation. Therefore, it is becoming increasingly important to quantify the in vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before and 2 months after cataract extraction. Images of the ciliary body will be compared visually using Adobe Photoshop 7.0.

Study Design

Study Type:

Interventional

Actual Enrollment :

15 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

Double (Investigator, Outcomes Assessor)

Primary Purpose:

Basic Science

Official Title:

The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Study Start Date :

May 1, 2006

Anticipated Primary Completion Date :

Mar 1, 2008

Anticipated Study Completion Date :

Mar 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
Other: 1 ultrasound biomicrocopic examinations and pilocarpine instillation	Other: UBM with pilocarpine in presbyopia ultrasound biomicroscopic examination in both eyes 30 minutes after one drop of 2% pilocarpine hydrochloride (Ocucarpine®, Samil Pharm., Seoul, Korea) instillation before and two months after cataract surgery Other Names: UBM with pilocarpine

Arm

Intervention/Treatment

Other: 1

ultrasound biomicrocopic examinations and pilocarpine instillation

Other: UBM with pilocarpine in presbyopia

ultrasound biomicroscopic examination in both eyes 30 minutes after one drop of 2% pilocarpine hydrochloride (Ocucarpine®, Samil Pharm., Seoul, Korea) instillation before and two months after cataract surgery

Other Names:

UBM with pilocarpine

Outcome Measures

Primary Outcome Measures

ultrasound biomicroscopic findings (ciliary body axial length) [2 months before and after surgery]

Eligibility Criteria

Criteria

Ages Eligible for Study:

55 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Age : same or more than 55 years
Patients with senile cataract who are going to get cataract surgery

Exclusion Criteria:

Age : less than 55 years
Previous ocular disease other than cataract.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Samsung Medical Center	Seoul		Korea, Republic of	135-710

Sponsors and Collaborators

Samsung Medical Center

Investigators

Study Director: Changwon Kee, M.D., Department of Ophthalmology, Samsung Medical Center, Ilwon-dong, Kangnam-gu, Seoul, 135-710, Republic of Korea. E-mail: ckee@skku.edu