PBCSG: Preterm Birth Cohort Study in Guangzhou
Study Details
Study Description
Brief Summary
The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up the short-term and long-term outcomes of preterm childrens.
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Detailed Description
Preterm birth has become the leading cause of neonatal death and the second leading cause of death among children under five years of age. Preterm childrens are more susceptible to adverse health problems including brain injury and neurodevelopment delay, and are at risk of chronic diseases which could impair the health status and life quality later in life. However, the causes of preterm birth is still not clear, and there are no effective prediction and preventive strategies. The Preterm Birth Cohort Study in Guangzhou (PBCSG) will collect the epidemiological,clinical information and biological specimens including maternal blood,cord blood, placenta, children's blood and stool samples of preterm childrens and their mothers. More importantly, childrens' health status, physical and neurodevelopment will be followed up to late childhood and adolescence. The preterm birth cohort would help to explore the mechanism of preterm birth and to examine the short- and long-term influence of preterm birth on physical health and neurodevelopment of childrens.
Study Design
Outcome Measures
Primary Outcome Measures
- Neurodevelopment at early childhood [At age of 1 year]
Assessed by using the Gesell Developmental Schedules, which include adaptive, gross motor, fine motor, language, and social function domains. Higher score in each domain is considered a better outcome, while no more than 85 is defined as suspected development retardation
Secondary Outcome Measures
- Intelligence quotient of offspring [At age of 6 years old]
Assessed by using Wechsler's Intelligence Scale for Children (WISC), which can generate a full scale intelligence quotient score and five primary index scores including verbal comprehension, visual spatial, fluid reasoning, working memory, and processing speed. Intelligence quotient ranges from 40 to 160,in which less than 70 is defined as mental retardation
- Height changes during childhood and adolescence [At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year]
Measured by nurses in clinic using a standard tool
- Weight changes during childhood and adolescence [At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year]
Measured by nurses in clinic using a standard tool
- Change of intestinal flora during early childhood [At age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 years old]
Assessed by analyses of stool samples
- Changes of body fat percentage during early childhood [At age of 3 years, 6 years, 12 years and 18 years old]
Assessed by Dual Energy X-Ray Absorptiometry (defined as total mass of fat divided by total body mass)
- Changes of bone density during early childhood [At age of 3 years, 6 years, 12 years and 18 years old]
Assessed by Dual Energy X-Ray Absorptiometry
Eligibility Criteria
Criteria
Inclusion Criteria:
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Born before 37 weeks of gestation
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Born in Guangzhou Women and Children's Medical Center
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Intended to remain in Guangzhou for more than 3 years
Exclusion Criteria:
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Multiple birth
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Stillbirth
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With major congenital abnormalities
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Guangzhou Women and Children's Medical Center, China | Guangzhou | China |
Sponsors and Collaborators
- Guangzhou Women and Children's Medical Center
Investigators
- Principal Investigator: Xiu Qiu, MD,PhD, Guangzhou Women and Children's Medical Center, China
Study Documents (Full-Text)
None provided.More Information
Publications
- 2018090501