The Effects of Music Therapy on Near-infrared Spectroscopy and Electroencephalogram in Premature Infants
Study Details
Study Description
Brief Summary
Music has been consistently shown magic power in brain plasticity. Several study proved music can influence electronic activity of preterm infants' brain, while none study covered region oxygen metabolic. The investigators aim to discover the effects of music therapy on near-infrared spectroscopy and electroencephalogram in premature infants.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Previous studies of music therapy have made some achievements for adult Parkinson's disease, schizophrenia, depression, anxiety, post-traumatic stress and pediatric autism spectrum disorders. For newborns, studies mainly focused on the effects of basic vital signs, feeding and pain score decreasing. So far, no studies evaluating the effect of music therapy on brain oxygen metabolic and electronic activity.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: music therapy The infant will receive music therapy over 3 consecutive days and will obtain standard care as usual |
Other: music
music selected by musician
|
| No Intervention: control The infant does not receive any sound emission because the headphone will be turned off and will obtain standard care as experimental |
Outcome Measures
Primary Outcome Measures
- change of brain oxygen saturation [from the start of the intervention to the end of the 3rd day]
near-infrared spectroscopy to monitor brain oxygen saturation
Secondary Outcome Measures
- Burdjalov Scores of amplitude integrated electroencephalogram [from the start of the intervention to the end of the 3rd day]
electroencephalogram to monitor brain electronic activity, using Burdjalov developed cerebral function monitoring scoring system which including: (1)record continuity: assessed through observing the overall density of the sample tracing, scores ranged from 0 to 2；(2) presence of cyclic changes：refers to the emergence and progression of periods during monitoring，scores ranged from 0 to 5；（3）degree of voltage amplitude depression：estimated as the average lower microvolt level during the recording epoch ，scores ranged from 0 to 2；（4）bandwidth：reflects a combination of the voltage span (peak-to-trough) of the tracing and the magnitude of the electroencephalogram depression，scores ranged from 0 to 4. The minimum possible total score was 0, and the maximum was 13. Scores progressively increased with central nerve system maturation.
- change of heart rates [from the start of the intervention to the end of the 3rd day]
monitors recording heart rates
- change of respiratory rates [from the start of the intervention to the end of the 3rd day]
monitors recording respiratory rates
- change of pluse oxygen saturation [from the start of the intervention to the end of the 3rd day]
monitors recording transcutaneous oxygen saturation
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Postmenstrual age of 32-36+6 weeks.
-
Appropriate weight for gestational age.
-
To have signed an informed consent to participate in the study.
-
Have reached clinical stability.
Exclusion Criteria:
-
Have nervous system diseases or obvious nervous system symptoms.
-
Severe congenital diseases.
-
The maintenance of sedative or analgesic drugs.
-
Support with mechanical ventilation.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Children's Hospital of Fudan University | Shanghai | Shanghai | China | 201102 |
Sponsors and Collaborators
- Children's Hospital of Fudan University
Investigators
- Study Director: lai s wang, Ph.D, Children's Hospital of Fudan University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MTOBF