Prevalence of Bronchiectasis in COPD Patients
Study Details
Study Description
Brief Summary
The identification of bronchiectasis in COPD has been defined as a different clinical COPD phenotype with greater symptomatic severity, more frequent chronic bronchial infection and exacerbations, and poor prognosis. A causal association has not yet been proven, but it is biologically plausible that COPD, and particularly the infective and exacerbator COPD phenotypes, could be the cause of bronchiectasis without any other known etiology, beyond any mere association or comorbidity.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The relationship between bronchiectasis and COPD has generated several questions. Is there any real increased prevalence of bronchiectasis in patients with COPD? Does the presence of bronchiectasis have an impact on the clinical characteristics, prognosis, or response to treatment in COPD, to the extent that it can be considered a distinct clinical phenotype? Should bronchiectasis in patients with COPD be seen as merely a comorbidity, or as a consequence of the disease's natural history? Is there a causal relationship between COPD and bronchiectasis? If this is the case, what are the pathophysiological mechanisms responsible for this relationship? And, finally, what is the role of chronic bronchial infection and exacerbations in this relationship?
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Group A COPD patients with bronchiectasis |
Other: prevalence
percentage of bronchectasis in COPD and its effect as prognostic measure
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Group B COPD patients without bronchiectasis |
Other: prevalence
percentage of bronchectasis in COPD and its effect as prognostic measure
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Outcome Measures
Primary Outcome Measures
- Prevalence of Bronchiectasis in COPD [1 year]
percentage of bronchiectasis diagnosed by CT chest in COPD patients
Secondary Outcome Measures
- impact of bronchiectasis on COPD exacerbations [1 year]
number of exacerbations treated in or out of hospitals
- impact of bronchiectasis on COPD hospitalization [1 year]
number of hospital admissions with acute exacerbations
- impact of bronchiectasis on COPD intensive care admission [1 year]
number of admissions in respiratory ICU and need for mechanical or non invasive ventilation
Eligibility Criteria
Criteria
Inclusion Criteria:
- COPD patients based on GOLD 2019 criteria, stable or in exacerbation
Exclusion Criteria:
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acute pneumonia within 2 months
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malignancy
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congenital bronchiectasis ( immobile cilia syndrome, Kartagnar syndrome).
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Pregnancy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | AssiutU | Assiut | Egypt | 71111 |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AssiutU7