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Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma

Sponsor
Mingkai Lin (Other)
Overall Status
Completed
CT.gov ID
NCT03159780
Collaborator
(none)
808
Enrollment
1
Location
8
Actual Duration (Months)
101.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Clear-lens extraction has been considered as first-line therapy for primary angle closure glaucoma(PACG) and application of toric intraocular lens (IOLs) leads to better postoperative visual acuity, yet little is known about the prevalence of corneal astigmatism in PACG patients. We intend to make biometry examination for Chinese PACG patients, to obtain keratometry (K) , axial length (AL) and so on, and demographics data will also be recorded. We will study the prevalence of corneal astigmatism before glaucoma surgery in Chinese patients with PACG. Furthermore, differences of corneal astigmatism between primary angle-closure glaucoma and cataract patients will be explored. Finally, the prevalence of corneal astigmatism before glaucoma surgery in Chinese patients with PACG will be portrayed and can be instructive to the IOLs' manufactering.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Biometry examination contains keratometry (K) , axial length (AL), central anterior chamber depth, visual field loss(mean deviation, MD), choroidal thickness(CT), range of goniosynechia, and stage of PACG.

    Demographics data contains age, gender, and eye.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    808 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Cross-Sectional
    Official Title:
    Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma
    Actual Study Start Date :
    Jan 1, 2017
    Actual Primary Completion Date :
    Aug 31, 2017
    Actual Study Completion Date :
    Aug 31, 2017

    Outcome Measures

    Primary Outcome Measures

    1. Prevalence of corneal astigmatism [During preoperative screening (1 day)]

      Data of corneal astigmatism will be acquired through examination,and different types of corneal astigmatism will be diagnosed and seperated.Moreover,we will analyse the prevalence of corneal astigmatism,and compare among different age groups and different genders.Correlation between demographic features and data will be analysed,too.

    Secondary Outcome Measures

    1. Prevalence of keratometry [During preoperative screening (1 day)]

      Flat,steep and mean keratometry will be examined before glaucoma surgery. Moreover,we will analyse the prevalence of corneal astigmatism,and compare among different age groups and different genders.

    2. Prevalence of axial length [During preoperative screening (1 day)]

      Axial length will be measured by both IOL Master and A-scan, and data will be compared between different measurements,different genders and different age groups.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    40 Years to 100 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Patients who are phakic and aged 40 years or older , and had newly diagnosed primary angle closure with intraocular pressure 30 mm Hg or greater or primary angle-closure glaucoma, will be recruited during preoperative screening at Zhongshan Ophthalmic Center.
    Exclusion Criteria:
    • Patients with corneal disease, irregular astigmatism, previous corneal or intraocular surgery, or a history of ocular inflammation will be excluded.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Zhongshan Ophthalmic Center Guangzhou Guangdong China 510060

    Sponsors and Collaborators

    • Mingkai Lin

    Investigators

    • Principal Investigator: Mingkai Lin, MD, Zhongshan Ophthalmic Center, Sun Yat-sen University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Mingkai Lin, Head of Glaucoma Center, Zhongshan Ophthalmic Center, Sun Yat-sen University
    ClinicalTrials.gov Identifier:
    NCT03159780
    Other Study ID Numbers:
    • ZhongshanOC20170503
    First Posted:
    May 19, 2017
    Last Update Posted:
    Oct 31, 2017
    Last Verified:
    Oct 1, 2017
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Glaucoma
    Astigmatism
    Glaucoma, Angle-Closure

    Study Results

    No Results Posted as of Oct 31, 2017