Prevalence of Molar Incisor Hypomineralization Among Children Treated With Asthmatic Drugs Early in Their Lives
Study Details
Study Description
Brief Summary
The aim of this study is to assess the prevalence of molar incisor hypo mineralization among children who have been treated with asthmatic drugs during the first three years of life.
| Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The term Molar incisor hypo mineralization (MIH) was first introduced in 2001 as a developmental disorder of enamel characterized by hypo mineralization -of systemic origin - affecting the enamel of first permanent molars (PFM) ,frequently associated with affected permanent incisors.
The prevalence of MIH varies widely, ranging from 2.4 % to 40.2% in different populations. This wide variation may be due to differences in diagnostic criteria and methodologies used by the authors. Concerning the etiology of MIH it is mostly related to pre natal, perinatal, and post natal illness.
Asthma and asthmatic drugs have been proposed to be one of the etiological factors of MIH,Internationally, the mean prevalence of pediatric asthma is 10%.
Study Design
Outcome Measures
Primary Outcome Measures
- Prevalence of molar incisor hypo mineralization (MIH) [baseline]
- Clinical examination will be carried out by the principle investigator using mirror and probe to examine all surfaces of each first permanent molar &permanent incisors following the diagnostic criteria of MIH set by the European Academy of Pediatric Dentistry (EAPD)as following :Demarcated opacities: Enamel disintegration: Atypical restorations: Extracted teeth: Tooth sensitivity:
Secondary Outcome Measures
- the severity of MIH [baseline]
the severity of MIH will be recorded into three categories :Mild MIH , Moderate MIH, and Severe MIH
Eligibility Criteria
Criteria
Inclusion Criteria:
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Children from 8 to 12 years old with fully erupted first permanent molars and permanent incisors.
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Children who were patients of the Pediatric Pulmonary Clinic and had used asthma drugs (oral and inhaled bronchodilators or corticosteroids) during their first three years of life.
Exclusion Criteria:
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Children with any chronic disease
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Children with unerupted or partially erupted first permanent molars.
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Children using a fixed orthodontic appliance
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Children having extensive carious lesions that might mask dental enamel defects.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Agouza police hospital | Giza | Egypt |
Sponsors and Collaborators
- Cairo University
Investigators
- Principal Investigator: Marina G Azmy, BSc., BSc.Faculty of Dentistry, Cairo University, 2012
- Study Chair: Marwa A Foad, MSc, Lecturer of Pediatric Dentistry and Dental Health
- Study Director: soad Abd el Moneam, PhD, Associate Professor of Pediatric Dentistry and Dental Public Health
Study Documents (Full-Text)
None provided.More Information
Publications
- Guergolette RP, Dezan CC, Frossard WT, Ferreira FB, Cerci Neto A, Fernandes KB. Prevalence of developmental defects of enamel in children and adolescents with asthma. J Bras Pneumol. 2009 Apr;35(4):295-300. English, Portuguese.
- Loli D, Costacurta M, Maturo P, Docimo R. Correlation between aerosol therapy in early childhood and Molar Incisor Hypomineralisation. Eur J Paediatr Dent. 2015 Mar;16(1):73-7.
- Mastora A, Vadiakas G, Agouropoulos A, Gartagani-Panagiotopoulou P, Gemou Engesaeth V. Developmental defects of enamel in first permanent molars associated with use of asthma drugs in preschool aged children: A retrospective case-control study. Eur Arch Paediatr Dent. 2017 Apr;18(2):105-111. doi: 10.1007/s40368-017-0280-1. Epub 2017 Mar 2.
- Visweswar VK, Amarlal D, Veerabahu R. Prevalence of developmental defects of enamel in children and adolescents with asthma: a cross-sectional study. Indian J Dent Res. 2012 Sep-Oct;23(5):697-8. doi: 10.4103/0970-9290.107432.
- Wogelius P, Haubek D, Nechifor A, Nørgaard M, Tvedebrink T, Poulsen S. Association between use of asthma drugs and prevalence of demarcated opacities in permanent first molars in 6-to-8-year-old Danish children. Community Dent Oral Epidemiol. 2010 Apr;38(2):145-51. doi: 10.1111/j.1600-0528.2009.00510.x. Epub 2010 Jan 4.
- MIH and asthmatic children