Prevalence of Non-adherence to Medication Among Patients on Chronic Hemodialysis
Study Details
Study Description
Brief Summary
Background:
Non-adherence to medication among patients on chronic hemodialysis compromises treatment effects and results in increased morbidity, mortality and extensive costs to the healthcare system. To our knowledge, no studies have investigated the prevalence of non-adherence among Danish hemodialysis patients using a validated measure of non-adherence.
Aim:
The primary aim of this study was to investigate the prevalence of non-adherence among Danish patients on chronic hemodialysis measured by self-report.
Our second aim was to explore patients' beliefs about medicines and potential associations between beliefs and non-adherence to medication.
Our third aim was to explore the prevalence and severity of physical and emotional symptoms and potential associations with non-adherence to medication.
Design:
A multi-centre cross-sectional study according to the STROBE statement will be conducted from May 2019 - April 2021. The study will take place in the outpatient hemodialysis centres at three large University Hospitals in the Capital Region of Denmark.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Outcome Measures
Primary Outcome Measures
- the Morisky-Green-Levine scale (MAQ) [up to 8 months]
number of participants with non-adherence to medication assessed by scores of ≥1 indicating non-adherence
- Medication adherence report scale (MARS) [up to 8 months]
number of participants with non-adherence to medication assessed by scores of less than 25 points indicating non-adherence
Secondary Outcome Measures
- Beliefs about medicines (BMQ) [up to 8 months]
number of participants that believe the necessity of their medication outweighs the cost of taking it assessed by scores ranging fra - 20 to + 20, with a postivie number indicating that patients belief in the benefit of mediciations overweights concerns about taking them
- Dialysis symptom index [up to 8 months]
the overall symptom burden assessed by the total number of symptoms reported by each participant.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Clinical diagnosis of end stage kidney disease
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Must have received hemodialysis treatment ≥3 month at a hospital-based outpatient hemodialysis Centre
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Must be able to understand and speak Danish
Exclusion Criteria:
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cognitive impairment
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no current medication prescriptions
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Nephology | Copenhagen | Denmark |
Sponsors and Collaborators
- Rigshospitalet, Denmark
- Herlev Hospital
- Hillerod Hospital, Denmark
Investigators
- Principal Investigator: Bo Feldt-rasmussen, Professor, Department of Nephrology, Rigshospitalet
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NNF17OC0029778