Prevalence of Primary Aldosteronism in Patients With Stroke
Study Details
Study Description
Brief Summary
Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.
Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Single Arm All patients admitted to the Acute Stroke Unit |
Diagnostic Test: Aldosterone renin ratio
Aldosterone Renin Ratio to screen for Primary Aldosteronism
|
Outcome Measures
Primary Outcome Measures
- Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke [6 months]
Percentage of patients with confirmed Primary Aldosteronism using confirmatory test
Secondary Outcome Measures
- Accuracy of Screening test in early period post-stroke [3 months]
To determine if the screening blood test for primary aldosteronism performed within 1 week post-stroke is equally accurate compared to being performed 2-4 months post-stroke.
- Percentage of unilateral primary aldosteronism in patients admitted with acute stroke [6 months]
Percentage of unilateral PA amongst patients with stroke
- Percentage of patients with positive screening test in patients admitted with acute stroke [3 months]
- Blood pressure change after treatment for primary aldosteronism [12 months]
- Cardiac Complications [6 months]
Cardiac complications in patients with primary aldosteronism, compared to those without primary aldosteronism, as assessed by transthoracic echocardiography features of left ventricular hypertrophy / mass, and diastolic dysfunction
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age 21-80 years
-
Admitted with acute cerebrovascular accident (CVA) or transient ischemic attack (TIA) to the ASU, CGH
-
Patients with both ischemic and hemorrhagic strokes
Exclusion Criteria:
- Pregnant patients
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Changi General Hospital | Singapore | Singapore | 529889 |
Sponsors and Collaborators
- Changi General Hospital
Investigators
- Principal Investigator: Troy Puar, MRCP UK, Changi General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PA_CVA