Prevalence of Primary Aldosteronism in Young Adults With Acute Stroke

• Sponsor: Chongqing Medical University (Other)
• Overall Status: Completed
• CT.gov ID: NCT04203420
• Collaborator: (none)
• Enrollment: 116
• Location: 1
• Actual Duration (Months): 29.4
• Patients Per Site Per Month: 3.9

Study Details

Study Description

Brief Summary

The guideline requires clinical works to screen for primary aldosteronism(PA) in young adults with family history of stroke at early onset. But the prevalence of PA in young adults with stroke onset before 45 years old had never been investigated. The study aimed to discover the prevalence as well as the clinical characteristics between patients with PA and those without PA during stroke attack. In order to fulfill this objective, investigators intended to conduct a cross-sectional study by taking screening and confirmatory tests among young adults who once admitted due to early onset of acute stroke.

Condition or Disease	Intervention/Treatment	Phase
Primary Aldosteronism	Other: screening and confirmatory tests

Study Design

• Study Type: Observational
• Actual Enrollment: 116 participants
• Observational Model: Cohort
• Time Perspective: Cross-Sectional
• Official Title: Prevalence of Primary Aldosteronism in Young Adults With Acute Stroke
• Actual Study Start Date: Jul 1, 2017
• Actual Primary Completion Date: Nov 1, 2019
• Actual Study Completion Date: Dec 13, 2019

Arms and Interventions

Arm	Intervention/Treatment
patients with PA patients who finally been diagnosed with primary aldosteronism	Other: screening and confirmatory tests; screening test is a blood test of the ratio of plasma aldosterone concentration(PAC) and direct renin concentration(DRC), confirmatory test is Captopril Challenge test
patients without PA patients who finally been diagnosed without primary aldosteronism	Other: screening and confirmatory tests; screening test is a blood test of the ratio of plasma aldosterone concentration(PAC) and direct renin concentration(DRC), confirmatory test is Captopril Challenge test

Outcome Measures

Primary Outcome Measures

1. prevalence of PA [through study completion, an average of 2 years]

   to find out the proportion of PA patients in young adults with early onset of acute stroke

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 45 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• patients who were once admitted in the First affiliated hospital of Chongqing Medical university(CQMU), with stroke onset less than two weeks

Exclusion Criteria:

death, serious sequela with motor, comprehensive or linguistic dysfunction, patients unwilling to join in, etiology of trauma, infective or tumor disease, patients with impaired cardiac, renal or liver function during admission-

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	The First Affilated Hospital of Chongqing Medical University	Chongqing	Chongqing	China	400016

Sponsors and Collaborators

• Chongqing Medical University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Qifu Li, Head of Department of Endocrinology, Chongqing Medical University
• ClinicalTrials.gov Identifier: NCT04203420
• Other Study ID Numbers: PASTROKE
• First Posted: Dec 18, 2019
• Last Update Posted: Dec 18, 2019
• Last Verified: Dec 1, 2019

• Individual Participant Data (IPD) Sharing Statement: Undecided
• Plan to Share IPD: Undecided
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Stroke; Hyperaldosteronism

Study Results

No Results Posted as of Dec 18, 2019