MyEndo-PA: Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study
Study Details
Study Description
Brief Summary
This research focuses on the prevalence of Primary Aldosteronism in the Malaysian adult population.
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Detailed Description
Hypertension (HPT) is a very common disease, expensive to treat with serious morbidity and mortality. In Malaysia, from the NHMS III conducted in 2006, HPT affects more than 36% of adults. Essential HPT (HPT with no identifiable cause) accounts for approximately 85% of cases, whereas 15% have identifiable conditions (secondary cause). The detection of a secondary cause of HPT is important as the condition is reversible when detected early. Primary aldosteronism (PA) has been identified as the commonest cause of secondary HPT. At present, PA has been regarded as the commonest and potentially curable, with a prevalence of 5-13% [1-7]. If this condition is detected early, the chances of cure from hypertension have been reported up to 80% of cases.
This will translate to a major impact to the Malaysian health-care budget. The costs spent on life-long BP medications and complications related to HPT can be reduced enormously. PA is a type of hormonal disorder that leads to high blood pressure (BP). In PA, the adrenal glands produce too much aldosterone causing sodium retention and potassium excretion. The excess sodium then increased the blood volume and BP.
Diagnosis and treatment of this condition are of paramount importance because people with this form of high BP have a higher risk of heart attack, stroke, kidney impairment, metabolic abnormality and reduce quality of life compared to patients with high BP not due to this condition. More importantly, the high BP associated with PA may be curable. This research will be conducted as a multicenter nation-wide study in Malaysia. The research aimed to study the prevalence of this disease in the investigators Malaysian population, determine the underlying mechanisms why this disease is associated with higher complication rate through cardiovascular and inflammatory markers, and identify the genes causing this disease, hence provide a more rapid diagnostic test and possibility of curing the disease with genetic therapy
Study Design
Outcome Measures
Primary Outcome Measures
- Aldosterone-Renin Ratio [Day 0]
Aldosterone-renin ratio of respondent at the time of sampling
Secondary Outcome Measures
- Level of Inflammatory Markers [Day 0]
Level of inflammatory markers (IL-6, hs-CRP) among respondents at the time of sampling
- Level of cardiovascular markers [Day 0]
Level of cardiovascular markers (BNP, PAI-1) among respondents at the time of sampling
Eligibility Criteria
Criteria
Inclusion Criteria:
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18 years old and above
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Malaysian citizen
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Consent given
Exclusion Criteria:
- Those who refused consent
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- International Islamic University Malaysia
- Malaysian Endocrine and Metabolic Society
- National University of Malaysia
- University of Malaya
- International Medical University
Investigators
- Principal Investigator: Nor Azmi Kamaruddin, FACE, Malaysian Endocrine and Metabolic Society
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MyEndo - PA