Early Detection and Intervention for Women At-risk of Psychosis
Study Details
Study Description
Brief Summary
This study aims to examine the effectiveness of the cognitive behavioral therapy in preventing the conversion of psychosis in a sample of individuals at-risk for psychosis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Eligible subjects with informed consent provided will be randomly assigned to the cognitive behavioural therapy (CBT) group or psychoeducation group. Each group consists of 8 session spanning for 8 week.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: CBT group This intervention aims for distress reduction, symptom coping, and life quality enhancement. It is a gender-specific CBT tailor-made for the at-risk population. The intervention is delivered by a registered clinical psychologist. |
Behavioral: CBT
A total of 8 CBT sessions will be provided to the participants, each session lasts for approximately 1.5 hour.
|
| Active Comparator: Psychoeducation group The content of the psycho-education program will be related to healthy living content and mental health knowledge, such as food hygiene, psychological well-being, knowledge about psychosis and common mental disorder and food nutrition. In addition, a weekly call to remind the subject about healthy living will also be provided to the subjects. The intervention is delivered by a registered social worker. |
Behavioral: Psychoeducation
A total of 8 psychoeducation sessions will be provided to the participants, each session lasts for approximately 1.5 hour.
|
Outcome Measures
Primary Outcome Measures
- Functioning: Measured by Social and Occupational Functioning Assessment Scale (SOFAS) [Changes from baseline to immediate, 6- and 12-month post-intervention]
Measured by Social and Occupational Functioning Assessment Scale (SOFAS). The SOFAS is an observer rating scale. Ratings should be based on subject's behavior during the last 1 month. The score ranges from 0-100. A higher score represents a better outcome.
- Functioning: Measured by Role Functioning Scale (RFS) [Changes from baseline to immediate, 6- and 12-month post-intervention]
Measured by Role Functioning Scale (RFS). The RFS is comprised of four single rating scaled for evaluating the functioning of individuals in specified areas of everyday life. The four role functions assessed are:(1)Working: productivity, (2) Independent living and self care, (3) Immediate social network relationships, and (4) Extended social network relationship. The values on each of the four scales range from 1 (minimal level of role functioning), to 7 (hypothetically optimal level of role functioning). Each of the seven points on the scales is accompanied by a behaviorally defined description.
- Conversion of psychosis [12-month post-intervention]
Proportion of subject that convert from at-risk state to psychosis
Secondary Outcome Measures
- Positive psychotic symptoms [Immediate, 6- and 12-month post-intervention]
Measurement of positive symptoms using the Chinese version of the Psychotic Symptom Rating Scales (C-PSYRATS). It comprises of the auditory hallucinations (AHS) and delusions subscales (DS). The AHS has 11 questions and the DS consists of 6 questions, each question has the responses ranging from 0-4. The higher score represents more severe positive psychotic symptoms.
- Beliefs about the auditory hallucination [Immediate, 6- and 12-month post-intervention]
Measured by the Beliefs About Voices Questionnaire (BAVQ-R). The BAVQ-R has 35 questions, the 4 responses range from disagree, unsure, slightly agree to strongly agree. The higher score represents more convicted belief about the voices.
- Depressive symptoms [Immediate, 6- and 12-month post-intervention]
Measured by the Calgary Depression Scale for Schizophrenia (CDSS). The scale consists of 9 questions, each has the response ranging from 0 to 3. The higher score presents more severe depressive symptoms.
- Social anxiety :Measured by Liebowitz Social Anxiety Scale (LSAS) [Immediate, 6- and 12-month post-intervention]
Measured by Liebowitz Social Anxiety Scale (LSAS). The LSAS consists of 24 questions, the rater has to rate from 0-3 in Fear or Anxiety domain or Avoidance domain for each of the 24 questions. The higher score represents more severe social anxiety.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
women of age 18-64
-
at-risk mental state as defined by the Comprehensive Assessment of At-Risk Mental States (CAARMS)
-
with an informed consent
-
able to understand Cantonese and read/write Chinese
Exclusion Criteria:
-
those mental conditions that requires other treatment priorities (e.g., suicidal risk, substance abuse, current or past episodes of psychotic disorder, personality disorders)
-
those medical conditions that severely limits participation, comprehension, or adherence to the treatment (e.g., epilepsy, dementia, terminal medical illness);
-
those who are receiving structured psychotherapy or counselling
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Hong Kong | Hong Kong | Hong Kong | 0000 |
Sponsors and Collaborators
- The University of Hong Kong
Investigators
- Principal Investigator: Eric Yu Hai Chen, MD, The University of Hong Kong
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- JCWowCBT
- UW 18-231