Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia

Sponsor

Assiut University (Other)

Overall Status

Completed

CT.gov ID

NCT04739748

Collaborator

(none)

136

Enrollment

Location

Actual Duration (Months)

6.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.

Condition or Disease	Intervention/Treatment	Phase
Ventilator Associated Pneumonia	Diagnostic Test: complete blood picture

Detailed Description

Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. VAP continues to be a leading cause of morbidity and mortality in the nosocomial setting. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases.

Study Design

Study Type:

Observational

Actual Enrollment :

136 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia

Actual Study Start Date :

Apr 6, 2018

Actual Primary Completion Date :

Dec 7, 2019

Actual Study Completion Date :

Dec 7, 2019

Arms and Interventions

Arm	Intervention/Treatment
Respiratory ICU patient patient in RICU that developed ventilator-associated pneumonia	Diagnostic Test: complete blood picture Measure the red blood cell distribution width (RDW), the neutrophil-lymphocyte ratio (NLR).

Arm

Intervention/Treatment

Respiratory ICU patient

patient in RICU that developed ventilator-associated pneumonia

Diagnostic Test: complete blood picture

Measure the red blood cell distribution width (RDW), the neutrophil-lymphocyte ratio (NLR).

Outcome Measures

Primary Outcome Measures

Hospital Mortality [45 days]
The number of patients who not Survive after developing ventilator-associated pneumonia in their stay in the Respiratory Intensive Care Unit.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Respiratory failure needs mechanical ventilator support > 48 hrs. VAP was defined as an acute lower respiratory tract infection in mechanically ventilated patient > 48 hrs with a new or progressing infiltrate on chest radiograph and who met at least two of the following clinical criteria: body temperature >38°C or <36°C with no other recognized cause, white blood cell count >10,000 /mm3 or <5000 /mm3, or a macroscopically purulent tracheal aspirate
Only the first VAP episode was included

Exclusion Criteria:

Neutropenia (< 500 cells/ml) before the development of VAP.
Conditions are known to influence total and differential WBC counts such as chronic inflammatory conditions, hematologic disorders, history of chemotherapy, or radiotherapy within 4 weeks before enrollment.
Conditions are known to affect RDW as anemia due to nutritional deficiency (ie, iron, vitamin B12, and folic acid).
Patients with HIV/AIDS