Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival
Study Details
Study Description
Brief Summary
This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Retrospective cohort study carried on 229 patients with non-metastatic rectal cancer, admitted in tertiary hospitals along 10 years, between 2012 to 2022, and underwent radical resection surgery with curative intent.
Exclusion criteria included patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, early post-operative recurrence or death within 3 months. Demographic, histopathological, follow up and outcome data were collected.
Demographics included age, gender, family history, and chief complaint at presentation. Histopathological data included tumor site, grade, vascular-perineural invasion, total number of lymph nodes removed, and positive lymph nodes.
Lymph node ratio was defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in histopathology specimen. Survival was calculated for each patient based on time of surgery to time of death
Statistical analysis will be used to evaluate the effect of lymph node ratio on overall survival.
Study Design
Outcome Measures
Primary Outcome Measures
- Overall Survival [up to 10 years (From date of surgery to the date date of death)]
Survival was calculated for each patient based on time of surgery to time of death.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patient with rectal cancer of stage I-III.
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patients underwent radical resection with curative intent.
Exclusion Criteria:
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Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers.
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Early post-operative recurrence, or death within 3 months.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Qena Faculty of Medicine, South Valley University Hospitals | QinÄ | Egypt |
Sponsors and Collaborators
- South Valley University
Investigators
- Principal Investigator: Abdallah M Taha, MD, Egypt, South Valley University, Faculty of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
- Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR, Winchester DP. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin. 2017 Mar;67(2):93-99. doi: 10.3322/caac.21388. Epub 2017 Jan 17.
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum In: CA Cancer J Clin. 2020 Jul;70(4):313.
- Le Voyer TE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ, Haller DG. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol. 2003 Aug 1;21(15):2912-9. doi: 10.1200/JCO.2003.05.062.
- Li Destri G, Di Carlo I, Scilletta R, Scilletta B, Puleo S. Colorectal cancer and lymph nodes: the obsession with the number 12. World J Gastroenterol. 2014 Feb 28;20(8):1951-60. doi: 10.3748/wjg.v20.i8.1951.
- Tepper JE, O'Connell MJ, Niedzwiecki D, Hollis D, Compton C, Benson AB 3rd, Cummings B, Gunderson L, Macdonald JS, Mayer RJ. Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol. 2001 Jan 1;19(1):157-63. doi: 10.1200/JCO.2001.19.1.157.
- SVU-MED-SUR011-4-22-10-464